Triterpenoids of Euphorbia kansuensis Proch

• Published in: Fitoterapia Vol. 83; no. 7; pp. 1242 - 1247
• Main Authors: Zhang, Bei-bei, Han, Xue-lian, Jiang, Qian, Liao, Zhi-xin, Liu, Chao, Qu, Yan-bo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.2012; Elsevier
• Subjects: Anti-inflammatory activity; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Anti-tumor activity; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Biological and medical sciences; Candida albicans; Euphorbia; Euphorbia - chemistry; Euphorbia kansuensis Proch; General pharmacology; HeLa Cells; Hep G2 Cells; Humans; Medical sciences; Microbial Sensitivity Tests; minimum inhibitory concentration; Molecular Structure; nuclear magnetic resonance spectroscopy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Triterpenes - isolation & purification; Triterpenes - pharmacology; Triterpenes - therapeutic use; Triterpenoid; triterpenoids; Anti-inflammatory activity; Euphorbia kansuensis Proch; Triterpenoid; Anti-tumor activity; Antineoplastic agent; Terpenoid; Pharmacognosy; Antiinflammatory agent; Medicinal plant; Euphorbia; Dicotyledones; Angiospermae; Plant origin; Triterpene; Euphorbiaceae; Spermatophyta
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2012.06.009

Phytochemical investigation of the ethanol extract of Euphorbia kansuensis Proch. led to the isolation of three new triterpenoids, along with ten known compounds. Their structures were established by extensive 1D and 2D NMR, as well as other spectrum analysis. Biological activities of the three new compounds against Hela cell, Hep-G2 cell, C. albicans ATCC10231 cell and SC5314 cell were evaluated. They showed strong anti-tumor and moderate anti-inflammatory activities with MIC values ranging from 13 to 25μg/ml and from 30 to 128μg/ml. [Display omitted]