PLACENTAL TRANSMISSION OF ATROPINE AT FULL-TERM PREGNANCY

Measurements of placental transmission of atropine were performed during Caesarean section. Twenty-five patients received H-atropine 0.5 μg. kg−1 i.v. 1–30 min before delivery. Maternal venous blood was sampled before the induction of anaesthesia and at the moment of delivery, together with umbilica...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 49; no. 10; pp. 1017 - 1021
Main Authors KIVALO, I., SAARIKOSKI, S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1977
Oxford University Press
Subjects
Adult
Anesthesia, Obstetrical
Atropine - blood
Atropine - metabolism
Cesarean Section
Female
Fetal Blood - analysis
Humans
Maternal-Fetal Exchange
Placenta - metabolism
Pregnancy
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Summary:Measurements of placental transmission of atropine were performed during Caesarean section. Twenty-five patients received H-atropine 0.5 μg. kg−1 i.v. 1–30 min before delivery. Maternal venous blood was sampled before the induction of anaesthesia and at the moment of delivery, together with umbilical arterial and venous blood. Total hydrogen-3 activity was determined by liquid scintillation counting. The stability of H-atropine was confirmed by paper chromatography. The concentrations in the umbilical vein 1 and 5 min after injection were respectively 12% and 93% of the corresponding maternal value. Those in the umbilical artery were approximately 50% of those in the umbilical vein during the same period.
Bibliography:ark:/67375/HXZ-DBGMNN25-B
istex:E52D1AB0DC859DB37BAB3C192F751C716A38C0DD
ArticleID:49.10.1017
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/49.10.1017