Arginine–pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections

• Published in: Bioorganic & medicinal chemistry letters Vol. 19; no. 22; pp. 6317 - 6318
• Main Authors: Haebich, Dieter, Kroll, Hein-Peter, Lerchen, Hans-Georg
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.11.2009; Elsevier
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibacterials; Antibiotics. Antiinfectious agents. Antiparasitic agents; Arginine - chemistry; Arginine - pharmacology; Bacteria; Bacterial Infections - drug therapy; Biological and medical sciences; Cross Infection - drug therapy; Drug Interactions; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria - drug effects; Host–pathogen interaction; Immunomodulators; Immunostimulant; Medical sciences; Methicillin Resistance; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pyrimidines - chemistry; Pyrimidines - pharmacology; Signal transduction; Streptococcal Infections - drug therapy; Immunostimulant; Signal transduction; Host–pathogen interaction; Antibacterials; Rodentia; Biological activity; Host-pathogen interaction; Infection; Immunomodulator; α-Aminoacid; Vertebrata; Immunostimulant agent; Mammalia; Mouse; Animal; Bacteriosis; Pyrimidine derivatives; Conjugated compound; Chemical synthesis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.09.090

Arginine–pyrimidine conjugates represent a novel class of compounds that exhibits therapeutic and prophylactic activity in lethal infections by Gram-positive and Gram-negative bacteria without showing antibacterial activity in vitro. Arginine–pyrimidine conjugates represent a novel class of compounds that exhibits therapeutic and prophylactic activity in lethal infections by Gram-positive and Gram-negative bacteria without showing antibacterial activity in vitro.