Regulation of Renin Secretion and Arterial Pressure During Prolonged Baroreflex Activation: Influence of Salt Intake

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 64; no. 3; pp. 604 - 609
• Main Authors: HILDEBRANDT, Drew A, IRWIN, Eric D, CATES, Adam W, LOHMEIER, Thomas E
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.09.2014
• Subjects: Aldosterone - blood; Animals; Arterial hypertension. Arterial hypotension; Baroreflex - physiology; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure - physiology; Cardiology. Vascular system; Dogs; Dose-Response Relationship, Drug; Heart Rate - drug effects; Heart Rate - physiology; Hematocrit; Medical sciences; Models, Animal; Neurotransmitter Agents - metabolism; Renin - blood; Renin - secretion; Sodium Chloride, Dietary - pharmacology; Hypertension; Enzyme; Secretion; Cardiovascular disease; Activation; Sympathetic nervous system; Peptidases; Salt; Regulation(control); Renin angiotensin system; Renin; Autonomic nervous system; Baroreflex; Hydrolases; Arterial pressure; Aspartic endopeptidases; Hemodynamics; Circulatory system; renin-angiotensin system; Prolonged; arterial pressure; baroreflex; sympathetic nervous system; renin–angiotensin system
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.114.03788

Chronic electric activation of the carotid baroreflex produces sustained reductions in sympathetic activity and arterial pressure and is currently being evaluated as antihypertensive therapy for patients with resistant hypertension. However, the influence of variations in salt intake on blood pressure lowering during baroreflex activation (BA) has not yet been determined. As the sensitivity of arterial pressure to salt intake is linked to the responsiveness of renin secretion, we determined steady-state levels of arterial pressure and neurohormonal responses in 6 dogs on low, normal, and high salt intakes (5, 40, 450 mmol/d, respectively) under control conditions and during a 7-day constant level of BA. Under control conditions, there was no difference in mean arterial pressure at low (92±1) and normal (92±2 mm Hg) sodium intakes, but pressure increased 9±2 mm Hg during high salt. Plasma renin activity (2.01±0.23, 0.93±0.20, 0.01±0.01 ng angiotensin I/mL/h) and plasma aldosterone (10.3±1.9, 3.5±0.5, 1.7±0.1 ng/dL) were inversely related to salt intake, whereas there were no changes in plasma norepinephrine. Although mean arterial pressure (19-22 mm Hg) and norepinephrine (20%-40%) were lower at all salt intakes during BA, neither the changes in pressure nor the absolute values for plasma renin activity or aldosterone in response to salt were different from control conditions. These findings demonstrate that suppression of sympathetic activity by BA lowers arterial pressure without increasing renin release and indicate that changes in sympathetic activity are not primary mediators of the effect of salt on renin secretion. Consequently, blood pressure lowering during BA is independent of salt intake.