SESN2 Could Be a Potential Marker for Diagnosis and Prognosis in Glioma
(1) Background: Glioma is among the most common brain tumors, and is difficult to eradicate with current therapeutic strategies due to its highly invasive and aggressive characteristics. Sestrin2 ( ) is an autophagy inducer. The effect of on glioma is controversial and unclear. (2) Methods: We downl...
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Published in | Genes Vol. 14; no. 3; p. 701 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
12.03.2023
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | (1) Background: Glioma is among the most common brain tumors, and is difficult to eradicate with current therapeutic strategies due to its highly invasive and aggressive characteristics. Sestrin2 (
) is an autophagy inducer. The effect of
on glioma is controversial and unclear. (2) Methods: We downloaded related RNA-seq data from the TCGA and GTEx databases. Bioinformatic analyses including differential gene expression analysis, KM survival curve analysis, univariate and multivariate Cox regression analyses, nomogram analysis, ROC curve analysis, gene function enrichment analysis, and immune cell infiltration analysis were conducted. In addition, data from the Human Protein Atlas (HPA) database were collected to validate
expression in glioma. (3) Results: In comparison with normal tissue, expression of
in glioma tissue was higher, and those with higher expressions had significantly lower overall survival rates. The results of univariate Cox regression analyses showed that
can be a disadvantageous factor in poor glioma prognosis. Both nomograms and ROC curves confirmed these findings. Meanwhile, according to gene function analysis,
may be involved in immune responses and the tumor microenvironment (TME). Based on the HPA database results,
is localized in the cytosol and shows high expression in glioma. (4) Conclusions: The expression of
in gliomas was positively relevant to a poorer prognosis, suggesting that
could be used as a prognostic gene. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
ISSN: | 2073-4425 2073-4425 |
DOI: | 10.3390/genes14030701 |