Selective synthesis of 2-pyridones and pyrimidine-2,4-diones by neutral rhodium(I) complex-catalyzed cyclocotrimerization of alkynes and isocyanates

A neutral rhodium(I) complex, ‘RhCl(PPh 3) 2’ generated by the combination of [RhCl(C 2H 4) 2] 2 with a fourfold amount of PPh 3, effectively catalyzed the cyclocotrimerization of alkynes ( 1) and isocyanates ( 2) to give 2-pyridones ( 3) and/or pyrimidine-2,4-diones ( 4), selectively, by controllin...

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 39; pp. 7107 - 7111
Main Authors Kondo, Teruyuki, Nomura, Masato, Ura, Yasuyuki, Wada, Kenji, Mitsudo, Take-aki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 25.09.2006
Elsevier
Subjects
2-Pyridone
Catalyst
Chemistry
Chemistry, Organic
Cyclocotrimerization
Physical Sciences
Pyrimidine-2,4-dione
Ruthenium
Science & Technology
Cyclocotrimerization
Ruthenium
2-Pyridone
Pyrimidine-2,4-dione
Catalyst
ruthenium
CYCLOADDITION
pyrimidine-2,4-dione
NICKEL
catalyst
CONSTRUCTION
2-pyridone
cyclocotrimerization
<2&2&2'>-CYCLOADDITION
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Summary:A neutral rhodium(I) complex, ‘RhCl(PPh 3) 2’ generated by the combination of [RhCl(C 2H 4) 2] 2 with a fourfold amount of PPh 3, effectively catalyzed the cyclocotrimerization of alkynes ( 1) and isocyanates ( 2) to give 2-pyridones ( 3) and/or pyrimidine-2,4-diones ( 4), selectively, by controlling the molar ratio of alkynes ( 1) and isocyanates ( 2).
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.07.105