Class II Major Histocompatibility Complex-Deficient Mice Initially Control an Infection with Leishmania major but Succumb to the Disease
Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania m...
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Published in | The Journal of infectious diseases Vol. 171; no. 5; pp. 1302 - 1308 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.05.1995
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania major and the capacity of MHC class I-restricted T cells to mediate resistance to L. major. Class II MHC-deficient mice and control (C57BL/6, normal and nude) mice were infected with L. major. Although MHC class II-deficient mice were able to control infection more effectively than nude mice, cutaneous lesions on the mice eventually progressed, and parasite replication became uncontrolled. These results suggest that CD4 cells and MHC class II molecules are essential for resistance to L. major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections. |
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Bibliography: | istex:C0FAE268C7811BFAC9ABCCD6270C97DB63065935 ark:/67375/HXZ-TLBLBKCK-6 Present affiliations: Department of Comparative Medicine, Division of Infectious Diseases, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts (CM.T.); Transplantation Surgical Services, Massachusetts General Hospital, Boston (J.S.M.). Reprints or correspondence (present address): Dr. Richard G. Titus. Dept. of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/171.5.1302 |