Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but a...

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Published inNutrients Vol. 13; no. 11; p. 3714
Main Authors El Omari, Nasreddine, Bakrim, Saad, Bakha, Mohamed, Lorenzo, José M., Rebezov, Maksim, Shariati, Mohammad Ali, Aboulaghras, Sara, Balahbib, Abdelaali, Khayrullin, Mars, Bouyahya, Abdelhakim
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 22.10.2021
MDPI
Subjects
Cancer therapies
Cell cycle
Colorectal cancer
DNA methylation
Enzymes
Epigenetics
Gene expression
Herbal medicine
humans
Investigations
Ischemia
isothiocyanates
Kinases
Lung cancer
neoplasms
Prostate cancer
Proteins
quinones
Review
terpenoids
transcription (genetics)
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Summary:Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu13113714