Advances in Translational 3D Printing for Cartilage, Bone, and Osteochondral Tissue Engineering

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 36; pp. e2201869 - n/a
• Main Authors: Wang, Shenqiang, Zhao, Sheng, Yu, Jicheng, Gu, Zhen, Zhang, Yuqi
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.09.2022
• Subjects: 3D printing; Biomimetics; bone; Cartilage; Nanotechnology; osteochondral tissue; Regeneration; Spatial distribution; Structural hierarchy; Three dimensional printing; Tissue engineering
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202201869

The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and hierarchical organizations for translational tissue engineering remains challenging. 3D printing, an additive manufacturing technique, has revolutionized the field of tissue engineering by fabricating biomimetic tissue constructs with precisely controlled composition, spatial distribution, and architecture that can replicate both biological and functional native tissues. Therefore, 3D printing is gaining increasing attention as a viable option to advance personalized therapy for various diseases by regenerating the desired tissues. This review outlines the recently developed 3D printing techniques for clinical translation and specifically summarizes the applications of these approaches for the regeneration of cartilage, bone, and osteochondral tissues. The current challenges and future perspectives of 3D printing technology are also discussed. As an emerging additive manufacturing technique, 3D printing can produce personalized scaffolds with desirable architectures, adjustable physicochemical properties, and tunable biological functionalities, which has revolutionized the development of tissue engineering and showed significant potential for clinical transformation, especially in the field of cartilage, bone, and osteochondral tissue regeneration.