Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection

• Published in: Advanced materials (Weinheim) Vol. 25; no. 18; pp. 2594 - 2599
• Main Authors: Tao, Yu, Lin, Youhui, Huang, Zhenzhen, Ren, Jinsong, Qu, Xiaogang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 14.05.2013; WILEY‐VCH Verlag
• Subjects: Animals; Biomimetic Materials - chemistry; broad pH ranges; Calorimetry; Cancer; cancer cell detection; Catalysis; catalyst; Cell Line, Tumor; Cell Separation - methods; Colorimetry; enzyme mimetic; Gold - chemistry; gold nanoclusters; Graphene; graphene oxide; Graphite - chemistry; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles - chemistry; Mice; Models, Molecular; Molecular Conformation; Nanocomposites; Nanomaterials; Nanostructure; Oxides; Oxides - chemistry; Peroxidase - metabolism; Time Factors
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201204419

A synergistic graphene oxide–gold nanocluster (GO‐AuNC) hybrid has been constructed as an enzyme mimic that is able to show high catalytic activity over a broad pH range, especially at neutral pH. Importantly, the target‐functionalized hybrid has been applied as a robust nanoprobe for selective, quantitative, and fast colorimetric detection of cancer cells.