CEFODIZIME, AN AMINOTHIAZOLYLCEPHALOSPORIN V. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFODIZIME SERIES
The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC...
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Published in | Journal of antibiotics Vol. 40; no. 1; pp. 29 - 42 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
1987
Japan Antibiotics Research Association |
Subjects | |
Online Access | Get full text |
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Summary: | The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.40.29 |