CEFODIZIME, AN AMINOTHIAZOLYLCEPHALOSPORIN V. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFODIZIME SERIES

The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC...

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Published inJournal of antibiotics Vol. 40; no. 1; pp. 29 - 42
Main Authors BLUMBACH, JÜRGEN, DÜRCKHEIMER, WALTER, EHLERS, EBERHARD, FLEISCHMANN, KLAUS, KLESEL, NORBERT, LIMBERT, MICHAEL, MENCKE, BURKHARD, REDEN, JÜRGEN, SCHEUNEMANN, KARL H., SCHRINNER, ELMAR, SEIBERT, GERHARD, WIEDUWILT, MANFRED, WORM, MANFRED
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1987
Japan Antibiotics Research Association
Subjects
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Cefotaxime - analogs & derivatives
Cefotaxime - chemical synthesis
Cefotaxime - metabolism
Cefotaxime - pharmacology
Dogs
Half-Life
Indicators and Reagents
Kinetics
Medical sciences
Mice
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
Antibiotic
Structure activity relation
Animal
Preparation
Lactam
Antibacterial agent
Metabolism
Pharmacokinetics
In vitro
Biological activity
Cephalosporin
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Summary:The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.29