Streptozotocin‐Induced Diabetic Models in Mice and Rats

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also...

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Bibliographic Details
Published inCurrent protocols Vol. 1; no. 4; pp. e78 - n/a
Main Author Furman, Brian L.
Format Journal Article
LanguageEnglish
Published 01.04.2021
Subjects
high‐fat
hyperglycemia
insulin deficiency
insulin resistance
insulitis
mouse or rat
nicotinamide
streptozotocin
type 1 diabetes mellitus
type 2 diabetes mellitus
hyperglycemia
type 1 diabetes mellitus
insulitis
streptozotocin
high-fat
insulin deficiency
nicotinamide
type 2 diabetes mellitus
mouse or rat
insulin resistance
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Summary:Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2021 The Authors.
ISSN:2691-1299
2691-1299
DOI:10.1002/cpz1.78