Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint

This study examined the dependence of neurogenic and non-neurogenic synovial plasma extravasation on neutrophils. Perfusion of bradykinin into the knee joint produced both a rapid increase in the magnitude of plasma extravasation and a significant increase in number of neutrophils in the synovium. B...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 10; no. 18; p. 3821
Main Authors Lo, E J, Green, P G, Miao, F J, Relchling, D B, Levine, J D
Format Journal Article
LanguageEnglish
Published England 16.12.1999
Subjects
Animals
Bradykinin - pharmacology
Capillary Permeability - drug effects
Cell Movement - physiology
Ganglia, Sympathetic - cytology
Ganglia, Sympathetic - physiology
Knee Joint - cytology
Knee Joint - physiology
Leukocyte Count
Male
Neurons - physiology
Neutrophils - cytology
Neutrophils - drug effects
Neutrophils - physiology
Platelet Activating Factor - pharmacology
Rats
Rats, Sprague-Dawley
Online AccessGet more information

Cover

More Information
Summary:This study examined the dependence of neurogenic and non-neurogenic synovial plasma extravasation on neutrophils. Perfusion of bradykinin into the knee joint produced both a rapid increase in the magnitude of plasma extravasation and a significant increase in number of neutrophils in the synovium. Both bradykinin-induced plasma extravasation and neutrophil accumulation were dependent on sympathetic post-ganglionic neuron terminals, since both were blocked in sympathectomized rats. Platelet activating factor, which produces plasma extravasation independent of sympathetic neurons, did not increase the number of neutrophils in the synovium. These findings support the suggestion that bradykinin acts on sympathetic nerve terminals in the knee leading to attraction of neutrophils, which promotes plasma extravasation.
ISSN:0959-4965
DOI:10.1097/00001756-199912160-00018