DNA-mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near-Infrared Light Triggered Release

A simple DNA‐mediated solvothermal method has been developed for the construction of well‐defined hollow UNPs that can be used for a new paradigm to realize NIR light‐controlled non‐invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 26; no. 15; pp. 2424 - 2430
Main Authors Zhou, Li, Chen, Zhaowei, Dong, Kai, Yin, Meili, Ren, Jinsong, Qu, Xiaogang
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 16.04.2014
Subjects
Benzopyrans - chemistry
beta-Galactosidase - metabolism
DNA
DNA - chemistry
Enzymes - metabolism
HeLa Cells
hollow particles
Humans
Immunoglobulin G - metabolism
Indoles - chemistry
Infrared Rays
Microscopy, Confocal
Microscopy, Electron, Transmission
nanoparticles
Nanoparticles - chemistry
near-infrared light
Nitro Compounds - chemistry
Ovalbumin - metabolism
protein delivery
solvothermal method
upconversion
near-infrared light
nanoparticles
protein delivery
DNA
solvothermal method
upconversion
hollow particles
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Summary:A simple DNA‐mediated solvothermal method has been developed for the construction of well‐defined hollow UNPs that can be used for a new paradigm to realize NIR light‐controlled non‐invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living cells. Intracellular NIR triggers the release of enzymes with high spatial and temporal precision and the released enzyme also retains its biological activity.
Bibliography:istex:DD12997F76CC5FF93BD856D6F970F4809FC9E5F8
ark:/67375/WNG-K0WBMS0Q-P
ArticleID:ADMA201304437
National Basic Research Program of China - No. 2012CB720602; No. 2011CB936004
National Natural Science Foundation of China - No. 21210002; No. 91213302; No. 21072182
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201304437