Disseminated Necrotizing Leukoencephalopathy Complicating Septic Shock in an Immunocompetent Patient

• Published in: Case Reports in Critical Care Vol. 2017; no. 2017; pp. 1 - 4
• Main Authors: Santos, João Meneses, Braz, Sandra, Reimão, Sofia, Gaspar-da-Costa, Pedro, Victorino, Rui M. M.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; Hindawi Limited; Wiley
• Subjects: Abdomen; Antibiotics; Case Report; Case studies; Coma; Complications and side effects; Critical care medicine; Edema; Fever; Gangrene; Hypertension; Laboratories; Leukemia; Leukoencephalopathy; Lymphoma; Medical imaging; Medicine; Metabolism; Nervous system; NMR; Nuclear magnetic resonance; Patients; Risk factors; Sepsis; Septic shock; Urine
• ISSN: 2090-6420; 2090-6439
• DOI: 10.1155/2017/1092537

Disseminated necrotizing leukoencephalopathy (DNL) is characterized by multiple microscopic foci of white matter necrosis. DNL was initially thought to be exclusively associated with immunosuppression conditions but it has been recently described in immunocompetent patients in septic shock. A 90-year-old immunocompetent woman with no previous neurological impairment presented with septic shock and drowsiness that responded well to therapy with clinical improvement and a full neurological recovery. Unexpectedly deterioration with progression to coma occurred. Investigation excluded other causes and Magnetic Resonance Imaging (MRI) was consistent with the diagnosis of DNL showing bilateral multifocal white matter lesions with a nonvascular pattern with restricted diffusion. Neurological impairment persisted with progression to death. DNL is an unexpected diagnosis in an immunocompetent patient. We compared the present case to those found in the literature of DNL complicating septic shock and discuss the antemortem diagnosis based on MRI findings.