Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of bo...

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Published inCancer Vol. 62; no. 11; pp. 2297 - 2300
Main Authors Leibovici, Leonard, Schoenfeld, Nili, Yehoshua, Henry A., Mamet, Rivka, Rakowsky, Erica, Shindel, Asher, Atsmon, Abraham
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.12.1988
Wiley-Liss
Subjects
Adult
Aged
Ammonia-Lyases - blood
Biological and medical sciences
Breast Neoplasms - enzymology
Female
Gastrointestinal Neoplasms - enzymology
Host-tumor relations. Immunology. Biological markers
Humans
Hydroxymethylbilane Synthase - blood
Leukocytes, Mononuclear - enzymology
Lung Neoplasms - enzymology
Male
Medical sciences
Middle Aged
Neoplasm Metastasis - enzymology
Ovarian Neoplasms - enzymology
Tumors
Human
Mononuclear cell
Enzymatic activity
Advanced stage
Tumor
Uroporphyrinogen I synthase
Tumoral marker
Metastasis
Cytochemistry
Blood
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Summary:Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7