Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer
Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of bo...
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Published in | Cancer Vol. 62; no. 11; pp. 2297 - 2300 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
01.12.1988
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0008-543X 1097-0142 |
DOI: | 10.1002/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7 |