The expression of LytM is down-regulated by RNAIII in Staphylococcus aureus
LytM is one kind of autolysin expressed in Staphylococcus aureus. It can hydrolyze peptide bond of pentaglycine, which is the component of cell wall. Until now, the regulation on the expression of LytM is still unclear. Here, we found that the level of LytM in the RNAIII mutant was increased. RNAIII...
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Published in | Journal of basic microbiology Vol. 52; no. 6; pp. 636 - 641 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.12.2012
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | LytM is one kind of autolysin expressed in Staphylococcus aureus. It can hydrolyze peptide bond of pentaglycine, which is the component of cell wall. Until now, the regulation on the expression of LytM is still unclear. Here, we found that the level of LytM in the RNAIII mutant was increased. RNAIII is an important small regulatory RNA in S. aureus. Our further investigation revealed that RNAIII can interact with the 5′UTR of lytM mRNA and block the ribosome binding sites [RBS]. So our results identified that LytM was the new target of RNAIII. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
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Bibliography: | National High-Tech Research and Development Program - No. 2006AA02Z132; No. 2006AA02Z323 ArticleID:JOBM201100426 istex:22BA3C8FF1EDD703240623041BE9C0C5802BACCC ark:/67375/WNG-T8BXRPDH-B National Natural Science Foundation of China - No. 30700007; No. 30870093; No. 30900019; No. 31000040 Chinese National Key Program on Basic Research - No. 2005CB724600 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0233-111X 1521-4028 |
DOI: | 10.1002/jobm.201100426 |