Digoxin-rifampin interaction

Digoxin doses required to maintain therapeutic serum concentrations rose substantially in two patients dependent on dialysis with the commencement of rifampin therapy. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective leve...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 35; no. 6; p. 750
Main Authors Gault, H, Longerich, L, Dawe, M, Fine, A
Format Journal Article
LanguageEnglish
Published United States 01.06.1984
Subjects
Digoxin - administration & dosage
Digoxin - blood
Drug Administration Schedule
Drug Interactions
Female
Humans
Kidney Failure, Chronic - therapy
Male
Middle Aged
Renal Dialysis
Rifampin - pharmacology
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Summary:Digoxin doses required to maintain therapeutic serum concentrations rose substantially in two patients dependent on dialysis with the commencement of rifampin therapy. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective levels with rifampin therapy and rise to potentially toxic levels when rifampin is discontinued.
ISSN:0009-9236
DOI:10.1038/clpt.1984.106