The Organometallic Approach to Molecular Diversity − Halogens as Helpers

Strategies to functionalize simple, though structurally challenging, compounds in regiodivergent manner are outlined. The starting materials are inexpensive (5−500 €/mol) arenes or heterocycles bearing heterosubstituents such as Cl, F, CF3, OCF3, and OCH3. A metal is introduced at the targeted posit...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2001; no. 21; pp. 3975 - 3984
Main Author Schlosser, Manfred
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 01.11.2001
WILEY‐VCH Verlag GmbH
Subjects
Building blocks
Combinatorial chemistry
Controllable metalation site-selectivity
Halogen shuffling
Hydrogen protection
Organofluorine compounds
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Summary:Strategies to functionalize simple, though structurally challenging, compounds in regiodivergent manner are outlined. The starting materials are inexpensive (5−500 €/mol) arenes or heterocycles bearing heterosubstituents such as Cl, F, CF3, OCF3, and OCH3. A metal is introduced at the targeted position either by direct hydrogen/metal exchange or, if this is not feasible, by use of organometallic precursor species as relay stations. The derivatives thus produced are versatile intermediates that may be employed as building blocks for further elaboration or even as scaffolds in combinatorial synthesis.
Bibliography:ArticleID:EJOC3975
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ark:/67375/WNG-LN010L8J-X
ISSN:1434-193X
1099-0690
DOI:10.1002/1099-0690(200111)2001:21<3975::AID-EJOC3975>3.0.CO;2-#