Correlation between TH1 response standard cytokines as biomarkers in patients with the delta virus in the western Brazilian Amazon

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 111; no. 4; pp. 275 - 276
• Main Authors: Nicolete, Larissa Deadame de Figueiredo, Borzacov, Lourdes Maria Pinheiro, Vieira, Deusilene Souza, Nicolete, Roberto, Salcedo, Juan Miguel Villalobos
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.04.2016; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Adult; Antiviral Agents - therapeutic use; Biomarkers - blood; Brazil; Cytokines - blood; Cytokines - immunology; Female; Genotype; HDV; Hepatitis D - drug therapy; Hepatitis D - virology; Hepatitis Delta Virus - immunology; Humans; Interferon alpha-2; Interferon-alpha - therapeutic use; Male; Middle Aged; PARASITOLOGY; patients treated; Polyethylene Glycols - therapeutic use; Polymerase Chain Reaction; Recombinant Proteins - therapeutic use; RNA, Viral; Short Communication; Th1 Cells - immunology; TH1 cytokines; TROPICAL MEDICINE; Viral Load; patients treated; TH1 cytokines; HDV
• ISSN: 0074-0276; 1678-8060; 1678-8060; 0074-0276
• DOI: 10.1590/0074-02760160035

Hepatitis D virus (HDV) is endemic in the Amazon Region and its pathophysiology is the most severe among viral hepatitis. Treatment is performed with pegylated interferon and the immune response appears to be important for infection control. HDV patients were studied: untreated and polymerase chain reaction (PCR) positive (n = 9), anti-HDV positive and PCR negative (n = 8), and responders to treatment (n = 12). The cytokines, interleukin (IL)-2 (p = 0.0008) and IL-12 (p = 0.02) were differentially expressed among the groups and were also correlated (p = 0.0143). Future studies will be conducted with patients at different stages of treatment, associating the viral load with serum cytokines produced, thereby attempting to establish a prognostic indicator of the infection.