The synthesis of azoxybacilin

(3H)‐Azoxybacilin, a new antifungal agent, was prepared in five steps. The label was introduced by reduction of 2‐t‐butoxycarbonylamino‐succinic‐acid‐1‐t‐butylester‐carbonic‐acid‐ethylester anhydride (2) with LiB3H4 generated from tritium gas via Li3H.

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Bibliographic Details
Published inJournal of labelled compounds & radiopharmaceuticals Vol. 38; no. 11; pp. 999 - 1005
Main Authors Huguenin, Philipp N., Shimma, Nobuo
Format Journal Article
LanguageEnglish
Published Chichester John Wiley & Sons, Ltd 01.11.1996
Wiley
Subjects
Aliphatic compounds
antifungal agent
azoxybacilin
Biochemical Research Methods
Biochemistry & Molecular Biology
Chemistry
Chemistry, Analytical
Chemistry, Medicinal
Exact sciences and technology
Life Sciences & Biomedicine
lithium borotritide
Organic chemistry
Pharmacology & Pharmacy
Physical Sciences
Preparations and properties
Science & Technology
tritium gas
azoxybacilin
antifungal agent
lithium borotritide
tritium gas
α-Aminoacid
Antifungal agent
Azoxy compound
Organic carbonate
Radiolabelling
Aliphatic compound
Tritium
Lithium Tetrahydroborates
Hydrogen Isotopes
Chemical synthesis
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Summary:(3H)‐Azoxybacilin, a new antifungal agent, was prepared in five steps. The label was introduced by reduction of 2‐t‐butoxycarbonylamino‐succinic‐acid‐1‐t‐butylester‐carbonic‐acid‐ethylester anhydride (2) with LiB3H4 generated from tritium gas via Li3H.
Bibliography:istex:829E84D7AAA3FB5DC54AB364E93F39012956A962
ark:/67375/WNG-7XJHC1CG-1
ArticleID:JLCR915
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0362-4803
1099-1344
DOI:10.1002/(SICI)1099-1344(199611)38:11<999::AID-JLCR915>3.0.CO;2-B