Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐cont...

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Published in	Advanced materials (Weinheim) Vol. 27; no. 41; pp. 6488 - 6495
Main Authors	Chen, Po-Jung, Kang, Yi-Da, Lin, Chen-Huan, Chen, San-Yuan, Hsieh, Chia-Hung, Chen, You-Yin, Chiang, Chun-Wei, Lee, Wei, Hsu, Chung-Y, Liao, Lun-De, Fan, Chih-Tai, Li, Meng-Lin, Shyu, Woei-Cherng
Format	Journal Article
Language	English
Published	Germany Blackwell Publishing Ltd 04.11.2015
Subjects	Animals Antigens, CD - metabolism Brain - diagnostic imaging Brain - pathology Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Contrast Media - chemistry Ferrosoferric Oxide - chemistry Flow Cytometry Gold - chemistry Homing Humans Imaging Magnetic resonance imaging Magnetite Nanoparticles - chemistry Male Mesenchymal Stem Cell Transplantation mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin Nanorods Nanostructure Nanotubes - chemistry Nanotubes - toxicity Nanotubes - ultrastructure photoacoustic imaging Radiography Stem cells Stroke - therapy Surgical implants Tracking Wharton Jelly - cytology magnetic resonance imaging photoacoustic imaging stroke therapy mesenchymal stem cells multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
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Abstract	A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long‐term monitoring to achieve therapeutic efficacy.
AbstractList	A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long‐term monitoring to achieve therapeutic efficacy.
Author	Chiang, Chun-Wei Lin, Chen-Huan Chen, You-Yin Kang, Yi-Da Chen, Po-Jung Liao, Lun-De Fan, Chih-Tai Shyu, Woei-Cherng Li, Meng-Lin Hsieh, Chia-Hung Chen, San-Yuan Hsu, Chung-Y Lee, Wei
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Keywords	magnetic resonance imaging photoacoustic imaging stroke therapy mesenchymal stem cells multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
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Snippet	A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are... A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are...
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SubjectTerms	Animals Antigens, CD - metabolism Brain - diagnostic imaging Brain - pathology Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Contrast Media - chemistry Ferrosoferric Oxide - chemistry Flow Cytometry Gold - chemistry Homing Humans Imaging Magnetic resonance imaging Magnetite Nanoparticles - chemistry Male Mesenchymal Stem Cell Transplantation mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin Nanorods Nanostructure Nanotubes - chemistry Nanotubes - toxicity Nanotubes - ultrastructure photoacoustic imaging Radiography Stem cells Stroke - therapy Surgical implants Tracking Wharton Jelly - cytology
Title	Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy
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