Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐cont...

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Published inAdvanced materials (Weinheim) Vol. 27; no. 41; pp. 6488 - 6495
Main Authors Chen, Po-Jung, Kang, Yi-Da, Lin, Chen-Huan, Chen, San-Yuan, Hsieh, Chia-Hung, Chen, You-Yin, Chiang, Chun-Wei, Lee, Wei, Hsu, Chung-Y, Liao, Lun-De, Fan, Chih-Tai, Li, Meng-Lin, Shyu, Woei-Cherng
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 04.11.2015
Subjects
Animals
Antigens, CD - metabolism
Brain - diagnostic imaging
Brain - pathology
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Contrast Media - chemistry
Ferrosoferric Oxide - chemistry
Flow Cytometry
Gold - chemistry
Homing
Humans
Imaging
Magnetic resonance imaging
Magnetite Nanoparticles - chemistry
Male
Mesenchymal Stem Cell Transplantation
mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mice
Mice, Inbred C57BL
multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
Nanorods
Nanostructure
Nanotubes - chemistry
Nanotubes - toxicity
Nanotubes - ultrastructure
photoacoustic imaging
Radiography
Stem cells
Stroke - therapy
Surgical implants
Tracking
Wharton Jelly - cytology
magnetic resonance imaging
photoacoustic imaging
stroke therapy
mesenchymal stem cells
multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
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Summary:A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long‐term monitoring to achieve therapeutic efficacy.
Bibliography:ark:/67375/WNG-TCZ1NG6G-D
National Chiao Tung University (NCTU) and The Ministry of Science and Technology of the Republic of China - No. NSC97-2314-B-039-036-MY3; No. NSC99-2632-B-039-001-MY3; No. NSC100-2314-B-039-002-MY3; No. NSC101-2321-B-039-004; No. NSC101-2321-B-039-006; No. NSC101-2321-B-039-008; No. NSC102-2325-B-039-006; No. NSC102-2325-B-039-001; No. NSC102-2221-E-007-012-MY3; No. MOST 102-2221-E-010-011-MY3; No. MOST 104-2632-B-039-002; No. MOST 102-2221-E-009-023-MY3
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ArticleID:ADMA201502784
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201502784