Effects of topical application and oral intake of Rosa Damascena on acute pain in adults: A systematic review and meta-analysis

• Published in: Oman medical journal Vol. 37; no. 5; pp. 1 - 14
• Main Authors: Koohpayeh, Seyedeh Atefeh, Hosseini, Meimanat, Nasiri, Morteza, Rezaei, Masoud
• Format: Journal Article
• Language: English
• Published: Muscat, Oman Oman Medical Specialty Board 01.09.2022; OMJ
• Subjects: acute pain; adult; Analgesia; Analgesics; Damask rose; Evaluation; iran; Meta-analysis; Oral medication; Physiological effect; Review; rosa
• ISSN: 1999-768X; 2070-5204
• DOI: 10.5001/omj.2022.33

Objectives: To conduct a systematic review and meta-analysis of available studies regarding the effects of the traditional herb Rosa damascena (as topical application and oral intake) on the severity of acute pain in adults. Methods: A systematic search was performed on the following databases: Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science Core Collection, Embase, Cumulative Index to Nursing and Allied Health Literature, Scientific Information Database, and Magiran from inception to 20 March 2021. We included parallel-group and cross-over randomized controlled trials that compared the effects of any products containing R damascena in oral and topical administration forms to placebo, non-treatment, or conventional treatment. Two researchers independently performed the document screening and selection, data extraction, and risk of bias assessment. A random-effect model was used to pool the data. Results: From a total of 11 studies that met the inclusion criteria, four studies administered R damascena through topical application and seven by oral intake. Nine studies recruited only females. Ten studies had parallel-group design, while one adopted cross-over design. The oral intake of R damascena reduced pain severity non-significantly (standardized mean difference (SMD) = -0.55, 95% CI: -1.27-0.17; p = 0.132). However, the topical application of this treatment had no pain-alleviating effect (SMD = 0.10, 95% CI: -0.75-0.96; p = 0.814). One study reported mild allergic rhinitis as an adverse effect of the treatment. Risk of bias assessment revealed that three of the eleven studies had good methodological quality, six had fair quality, and two were of poor quality. Conclusions: This systematic review and meta-analysis suggests that the oral intake of R damascena may have a non-significant alleviating effect on acute pain severity in adults. However, its topical application has not shown pain-alleviating effect. More robust randomized controlled trials are needed for accurate estimation of the effects of oral and topical use of R damascena on the severity of different types of acute pain in adults.