Cardiotonic 'C' ring modified isomazole analogues

• Published in: Archiv der Pharmazie (Weinheim) Vol. 323; no. 8; p. 507
• Main Authors: Barraclough, P, Black, J W, Cambridge, D, Demaine, D A, Gerskowitch, V P, Giles, H, Hill, A P, Hull, R A, Lyer, R, King, W R
• Format: Journal Article
• Language: English
• Published: Germany 1990
• Subjects: Animals; Cardiotonic Agents - chemical synthesis; Cardiotonic Agents - chemistry; Dogs; Female; Imidazoles - chemical synthesis; Imidazoles - chemistry; Imidazoles - pharmacology; Male

Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activ...