Cardiotonic 'C' ring modified isomazole analogues

Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activ...

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Bibliographic Details
Published inArchiv der Pharmazie (Weinheim) Vol. 323; no. 8; p. 507
Main Authors Barraclough, P, Black, J W, Cambridge, D, Demaine, D A, Gerskowitch, V P, Giles, H, Hill, A P, Hull, R A, Lyer, R, King, W R
Format Journal Article
LanguageEnglish
Published Germany 1990
Subjects
Animals
Cardiotonic Agents - chemical synthesis
Cardiotonic Agents - chemistry
Dogs
Female
Imidazoles - chemical synthesis
Imidazoles - chemistry
Imidazoles - pharmacology
Male
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Summary:Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activity. The 4'-methylsulphonyl, -cyano, -carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies.
ISSN:0365-6233
DOI:10.1002/ardp.19903230812