Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompati...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 28; no. 39; pp. 8760 - 8765
Main Authors Cai, Xiaolei, Bandla, Aishwarya, Mao, Duo, Feng, Guangxue, Qin, Wei, Liao, Lun-De, Thakor, Nitish, Tang, Ben Zhong, Liu, Bin
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.10.2016
Subjects
aggregation-induced emission
Biocompatibility
Blood-brain barrier
blood-brain barrier damage
Brain
Damage detection
Emission
Ischemia
Nanoparticles
photothrombotic ischemia
stroke
Toxicity
aggregation-induced emission
blood-brain barrier damage
nanoparticles
photothrombotic ischemia
stroke
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Summary:Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation‐induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.
Bibliography:ArticleID:ADMA201601191
Singapore National Research Foundation - No. R279-000-444-281
Institute of Materials Research and Engineering of Singapore - No. IMRE/14-8P1110
National University of Singapore - No. R279-000-415-112
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201601191