Inotropic activities of imidazopyridines

• Published in: Archiv der Pharmazie (Weinheim) Vol. 323; no. 8; p. 501
• Main Authors: Barraclough, P, Black, J W, Cambridge, D, Gerskowitch, V P, Hull, R A, Lyer, R, King, W R, Kneen, C O, Nobbs, M S, Shah, G P
• Format: Journal Article
• Language: English
• Published: Germany 1990
• Subjects: Anesthesia; Animals; Cardiotonic Agents - chemical synthesis; Dogs; Female; Guinea Pigs; Imidazoles - chemical synthesis; Imidazoles - pharmacology; In Vitro Techniques; Male; Papillary Muscles - drug effects; Pyridines - chemical synthesis; Pyridines - pharmacology; Structure-Activity Relationship

A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pi...