Inotropic activities of imidazopyridines

A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pi...

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Bibliographic Details
Published inArchiv der Pharmazie (Weinheim) Vol. 323; no. 8; p. 501
Main Authors Barraclough, P, Black, J W, Cambridge, D, Gerskowitch, V P, Hull, R A, Lyer, R, King, W R, Kneen, C O, Nobbs, M S, Shah, G P
Format Journal Article
LanguageEnglish
Published Germany 1990
Subjects
Anesthesia
Animals
Cardiotonic Agents - chemical synthesis
Dogs
Female
Guinea Pigs
Imidazoles - chemical synthesis
Imidazoles - pharmacology
In Vitro Techniques
Male
Papillary Muscles - drug effects
Pyridines - chemical synthesis
Pyridines - pharmacology
Structure-Activity Relationship
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Summary:A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.
ISSN:0365-6233
DOI:10.1002/ardp.19903230811