Inotropic activities of imidazopyridines
A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pi...
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| Published in | Archiv der Pharmazie (Weinheim) Vol. 323; no. 8; p. 501 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
1990
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| Subjects | |
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| Abstract | A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed. |
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| AbstractList | A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed. |
| Author | Nobbs, M S Hull, R A Lyer, R Black, J W Gerskowitch, V P Cambridge, D King, W R Kneen, C O Barraclough, P Shah, G P |
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| CitedBy_id | crossref_primary_10_1002_chin_199052203 crossref_primary_10_1007_BF00772931 crossref_primary_10_1016_j_ejmech_2014_03_019 crossref_primary_10_1002_ardp_19923250918 crossref_primary_10_1016_0223_5234_92_90004_K crossref_primary_10_1016_S0960_894X_01_81217_8 crossref_primary_10_1002_ardp_19923250407 |
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| Snippet | A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic... |
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| SubjectTerms | Anesthesia Animals Cardiotonic Agents - chemical synthesis Dogs Female Guinea Pigs Imidazoles - chemical synthesis Imidazoles - pharmacology In Vitro Techniques Male Papillary Muscles - drug effects Pyridines - chemical synthesis Pyridines - pharmacology Structure-Activity Relationship |
| Title | Inotropic activities of imidazopyridines |
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