Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil

Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections...

Full description

Saved in:
Bibliographic Details
Published inMemórias do Instituto Oswaldo Cruz Vol. 111; no. 11; pp. 663 - 669
Main Authors Lima, Júnior, Sérgio Ferreira de, Tavares, Mayara Mansur Fernandes, Macedo, Jamilly Lopes de, Oliveira, Renata Santos de, Heráclio, Sandra de Andrade, Maia, Maria de Mascena Diniz, Souza, Paulo Roberto Eleutério de, Moura, Ronald, Crovella, Sergio
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.11.2016
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Adolescent
Adult
Aged
Alleles
Base Sequence
Brazil
Cervical Intraepithelial Neoplasia - genetics
Cervical Intraepithelial Neoplasia - virology
Cross-Sectional Studies
cytokine
DNA, Viral - analysis
Female
Gene Frequency
Genetic Predisposition to Disease
host genome
HPV
Humans
Interleukin-6 - genetics
Interleukin-8 - genetics
Middle Aged
Papillomavirus Infections - genetics
Papillomavirus Infections - virology
PARASITOLOGY
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
polymorphisms
Transforming Growth Factor beta1 - genetics
TROPICAL MEDICINE
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - virology
Young Adult
cytokine
host genome
polymorphisms
HPV
Online AccessGet full text

Cover

Abstract Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus.
AbstractList Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus.
Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus.
Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus.
Author Macedo, Jamilly Lopes de
Moura, Ronald
Lima, Júnior, Sérgio Ferreira de
Maia, Maria de Mascena Diniz
Tavares, Mayara Mansur Fernandes
Souza, Paulo Roberto Eleutério de
Crovella, Sergio
Oliveira, Renata Santos de
Heráclio, Sandra de Andrade
AuthorAffiliation 6 Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brasil
4 Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil
2 Rede Nordeste de Biotecnologia, Recife, PE, Brasil
1 Universidade Federal de Pernambuco, Pós-Graduação em Biologia Aplicada à Saúde, Laboratório de Genoma, Recife, PE, Brasil
3 Universidade Federal Rural de Pernambuco, Recife, PE, Brasil
5 Universidade Federal Rural de Pernambuco,Departamento de Biologia, Recife, PE, Brasil
AuthorAffiliation_xml – name: 2 Rede Nordeste de Biotecnologia, Recife, PE, Brasil
– name: 5 Universidade Federal Rural de Pernambuco,Departamento de Biologia, Recife, PE, Brasil
– name: 3 Universidade Federal Rural de Pernambuco, Recife, PE, Brasil
– name: 6 Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brasil
– name: 4 Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil
– name: 1 Universidade Federal de Pernambuco, Pós-Graduação em Biologia Aplicada à Saúde, Laboratório de Genoma, Recife, PE, Brasil
– name: Universidade Federal Rural de Pernambuco
– name: Universidade Federal de Pernambuco
– name: Rede Nordeste de Biotecnologia
– name: Instituto de Medicina Integral Professor Fernando Figueira
Author_xml – sequence: 1
  givenname: Sérgio Ferreira de
  surname: Lima, Júnior
  fullname: Lima, Júnior, Sérgio Ferreira de
  organization: Universidade Federal de Pernambuco, Pós-Graduação em Biologia Aplicada à Saúde, Laboratório de Genoma, Recife, PE, Brasil
– sequence: 2
  givenname: Mayara Mansur Fernandes
  surname: Tavares
  fullname: Tavares, Mayara Mansur Fernandes
  organization: Universidade Federal de Pernambuco, Pós-Graduação em Biologia Aplicada à Saúde, Laboratório de Genoma, Recife, PE, Brasil
– sequence: 3
  givenname: Jamilly Lopes de
  surname: Macedo
  fullname: Macedo, Jamilly Lopes de
  organization: Rede Nordeste de Biotecnologia, Recife, PE, Brasil
– sequence: 4
  givenname: Renata Santos de
  surname: Oliveira
  fullname: Oliveira, Renata Santos de
  organization: Universidade Federal Rural de Pernambuco, Recife, PE, Brasil
– sequence: 5
  givenname: Sandra de Andrade
  surname: Heráclio
  fullname: Heráclio, Sandra de Andrade
  organization: Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil
– sequence: 6
  givenname: Maria de Mascena Diniz
  surname: Maia
  fullname: Maia, Maria de Mascena Diniz
  organization: Universidade Federal Rural de Pernambuco,Departamento de Biologia, Recife, PE, Brasil
– sequence: 7
  givenname: Paulo Roberto Eleutério de
  surname: Souza
  fullname: Souza, Paulo Roberto Eleutério de
  organization: Universidade Federal Rural de Pernambuco,Departamento de Biologia, Recife, PE, Brasil
– sequence: 8
  givenname: Ronald
  surname: Moura
  fullname: Moura, Ronald
  organization: Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brasil
– sequence: 9
  givenname: Sergio
  surname: Crovella
  fullname: Crovella, Sergio
  organization: Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brasil
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27783717$$D View this record in MEDLINE/PubMed
BookMark eNpVUk1vEzEQtVAR_YA7J-Qjh2yx15-5IEFFS6RIIFHOlteZTRy89mJni8oP4AfxQ_hN7DYhohePNfPem-fxnKOTmCIg9JKSSyrm5A0hilekVpJQSYigT9AZlUpXmkhygs6O5VN0XsqWjFcm-TN0WiulmaLqDP1axDYMEB3g1OLFspKz6dQzbOMK395cV39-U7yGCLhP4b5Lud_40hWcIt5tAGdfvk3MzdDZiHvb-xBSZ-98HkrlYwtu50eoj_hH6iDiNqcOf4YcbdcMLs3w-2x_-vAcPW1tKPDiEC_Q1-sPt1cfq-Wnm8XVu2XlOJW0krUlUgpKhRZQ11xp6hqpmGANa-dghbWWCdJSELqhLRUW3NzZRjJONSeSXaDFXneV7Nb02Xc235tkvXlIpLw2Nu-8C2C0Uo3kHKx1cy6ANFOktqk110y2fNS63GsV5yEks03D-KxQzJdp7maae_3wL5SS0TUbCW_3hH5oOlg5iLtswyMXjyvRb8w63RlBa0G4GgVeHwRy-j5A2ZnOFwch2AhpKIZqJqTiY78RSvZQl1MpGdpjG0rMtDvmaPKwOyPl1f_2joR_y8L-Asqovcs
CitedBy_id crossref_primary_10_1007_s00430_018_0557_y
crossref_primary_10_1186_s43088_022_00211_5
crossref_primary_10_12677_ACM_2021_113179
crossref_primary_10_3390_medicina57101025
crossref_primary_10_1016_j_intimp_2018_11_015
crossref_primary_10_18632_oncotarget_24033
crossref_primary_10_1089_mab_2022_0039
crossref_primary_10_3390_cells12010084
crossref_primary_10_1080_08820139_2020_1778023
crossref_primary_10_1007_s13204_022_02464_z
Cites_doi 10.1016/j.ejogrb.2011.05.019
10.1128/MMBR.65.1.131-150.2001
10.4238/2015.March.31.18
10.1089/107999001459150
10.1046/j.1365-2370.2002.00347.x
10.1056/NEJMoa021641
10.1073/pnas.91.9.3602
10.1073/pnas.94.7.3052
10.1002/(SICI)1097-0142(19990615)85:12<2526::AID-CNCR6>3.0.CO;2-3
10.2217/fon.12.59
10.3892/ol.2015.3295
10.1172/JCI2629
10.1016/j.clinbiochem.2004.01.014
10.1200/JCO.2005.02.047
10.1158/1055-9965.1547.13.9
10.1016/j.ejogrb.2008.04.007
10.1158/1055-9965.EPI-05-0446
10.1016/j.cyto.2012.04.013
10.1155/2013/146079
10.1016/j.jaci.2010.11.050
10.1016/j.cyto.2010.11.014
10.1215/S1152851704001061
10.1093/oxfordjournals.jncimonographs.a003480
10.1086/321291
10.1038/nrc798
10.2217/pgs.13.238
ContentType Journal Article
Copyright This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright_xml – notice: This work is licensed under a Creative Commons Attribution 4.0 International License.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
GPN
DOA
DOI 10.1590/0074-02760160051
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
SciELO
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1678-8060
EndPage 669
ExternalDocumentID oai_doaj_org_article_877b644eaac945e0bac941ab284836f4
S0074_02762016001100663
10_1590_0074_02760160051
27783717
Genre Journal Article
GroupedDBID -~X
123
29M
2WC
53G
5VS
79B
ABXHO
ADBBV
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APOWU
AZFZN
BAWUL
BCNDV
CGR
CUY
CVF
DIK
DU5
E3Z
ECM
EIF
F5P
FRP
GROUPED_DOAJ
GX1
HYE
IPNFZ
KQ8
M~E
NPM
OHT
OK1
RBI
RIG
RNS
RPM
RSC
SCD
XSB
ZGI
~02
AAYXX
CITATION
7X8
5PM
GPN
ID FETCH-LOGICAL-c4161-62a066511585e224781cb67353b3f9ea5aaa350f1e58b1f15aec9cab634184063
IEDL.DBID RPM
ISSN 0074-0276
1678-8060
IngestDate Tue Oct 22 15:11:01 EDT 2024
Fri Oct 18 20:39:49 EDT 2024
Tue Sep 17 20:30:17 EDT 2024
Fri Jun 28 08:09:30 EDT 2024
Fri Aug 23 01:04:17 EDT 2024
Sat Sep 28 07:59:50 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords cytokine
host genome
polymorphisms
HPV
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4161-62a066511585e224781cb67353b3f9ea5aaa350f1e58b1f15aec9cab634184063
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125047/
PMID 27783717
PQID 1835674110
PQPubID 23479
PageCount 7
ParticipantIDs doaj_primary_oai_doaj_org_article_877b644eaac945e0bac941ab284836f4
scielo_journals_S0074_02762016001100663
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5125047
proquest_miscellaneous_1835674110
crossref_primary_10_1590_0074_02760160051
pubmed_primary_27783717
PublicationCentury 2000
PublicationDate 2016-11-01
PublicationDateYYYYMMDD 2016-11-01
PublicationDate_xml – month: 11
  year: 2016
  text: 2016-11-01
  day: 01
PublicationDecade 2010
PublicationPlace Brazil
PublicationPlace_xml – name: Brazil
PublicationTitle Memórias do Instituto Oswaldo Cruz
PublicationTitleAlternate Mem Inst Oswaldo Cruz
PublicationYear 2016
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Fundação Oswaldo Cruz (FIOCRUZ)
Publisher_xml – name: Instituto Oswaldo Cruz, Ministério da Saúde
– name: Fundação Oswaldo Cruz (FIOCRUZ)
References 12750287 - Cancer Res. 2003 May 15;63(10):2610-5
12571259 - N Engl J Med. 2003 Feb 6;348(6):518-27
15831231 - Neuro Oncol. 2005 Apr;7(2):122-33
23936772 - Biomed Res Int. 2013;2013:146079
21167737 - Cytokine. 2011 Mar;53(3):282-5
12807943 - J Natl Cancer Inst Monogr. 2003;(31):35-40
22579115 - Cytokine. 2012 Jul;59(1):145-55
26622540 - Oncol Lett. 2015 Aug;10(2):600-606
10375098 - Cancer. 1999 Jun 15;85(12):2526-31
11238989 - Microbiol Mol Biol Rev. 2001 Mar;65(1):131-50
15087251 - Clin Biochem. 2004 May;37(5):363-9
11431705 - Am J Hum Genet. 2001 Aug;69(2):413-9
24444410 - Pharmacogenomics. 2014 Feb;15(2):209-19
21719187 - Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):330-3
9769329 - J Clin Invest. 1998 Oct 1;102(7):1369-76
12358852 - Eur J Immunogenet. 2002 Oct;29(5):417-21
15342460 - Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1547-9
8170954 - Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3602-6
22764769 - Future Oncol. 2012 Jun;8(6):713-22
21377040 - J Allergy Clin Immunol. 2011 Mar;127(3):701-21.e1-70
9096344 - Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3052-7
15774796 - J Clin Oncol. 2005 Mar 20;23(9):2078-93
12044010 - Nat Rev Cancer. 2002 May;2(5):342-50
25867437 - Genet Mol Res. 2015 Mar 31;14(1):2876-84
18502564 - Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):241-4
11177580 - J Interferon Cytokine Res. 2001 Jan;21(1):45-52
10914713 - Clin Cancer Res. 2000 Jul;6(7):2702-6
16214933 - Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2457-8
Akdis M (ref2) 2011; 127
Suárez-Kurtz G (ref26) 2014; 15
zur Hausen H (ref31) 2002; 2
Knall C (ref17) 1997; 94
(ref14) 2016
Stanczuk GA (ref25) 2002; 29
Nakashima J (ref21) 2000; 6
Song D (ref24) 2015; 10
Wang Q (ref27) 2011; 158
(ref13) 2012
Baker R (ref3) 2011; 53
Marangon AV (ref18) 2013
Wang SS (ref28) 2003; 31
Coelho AVC (ref6) 2015; 14
Fishman D (ref11) 1998; 102
Brat DJ (ref4) 2005; 7
Elliott RL (ref9) 2005; 23
Fernandes APM (ref10) 2008; 140
Wu X (ref30) 1994; 91
Campa D (ref5) 2005; 14
Mogensen TH (ref19) 2001; 65
Savage SA (ref23) 2004; 13
Palena C (ref22) 2012; 8
Hull J (ref12) 2001; 69
Kinoshita T (ref16) 1999; 85
Wang Y (ref29) 2012; 59
Kassim SK (ref15) 2004; 37
(ref1) 2002
de Vita F (ref7) 2001; 21
Muñoz N (ref20) 2003; 348
Dunning AM (ref8) 2003; 63
2011; 158
2015; 14
2012
2000; 6
2015; 10
2011; 53
2002; 2
1999; 85
2002
2012; 59
2001; 69
2003; 31
2005; 23
2008; 140
2001; 21
2001; 65
2011; 127
1997; 94
2003; 348
2002; 29
2004; 37
2004; 13
2014; 15
2005; 7
2016
2013
1994; 91
1998; 102
2003; 63
2012; 8
2005; 14
References_xml – volume: 158
  start-page: 330
  issue: 2
  year: 2011
  ident: ref27
  article-title: Association between cytokine gene polymorphisms and cervical cancer in a Chinese population
  publication-title: Eur J Obstet Gynecol Reprod Biol
  doi: 10.1016/j.ejogrb.2011.05.019
  contributor:
    fullname: Wang Q
– volume: 63
  start-page: 2610
  issue: 10
  year: 2003
  ident: ref8
  article-title: A transforming growth factor β1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer
  publication-title: Cancer Res
  contributor:
    fullname: Dunning AM
– volume: 65
  start-page: 131
  issue: 1
  year: 2001
  ident: ref19
  article-title: Molecular pathways in virus induced cytokine production
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.65.1.131-150.2001
  contributor:
    fullname: Mogensen TH
– volume: 14
  start-page: 2876
  issue: 1
  year: 2015
  ident: ref6
  article-title: A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil
  publication-title: Genet Mol Res
  doi: 10.4238/2015.March.31.18
  contributor:
    fullname: Coelho AVC
– year: 2016
  ident: ref14
– volume: 21
  start-page: 45
  issue: 1
  year: 2001
  ident: ref7
  article-title: Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicator
  publication-title: J Interferon Cytokine Res
  doi: 10.1089/107999001459150
  contributor:
    fullname: de Vita F
– volume: 29
  start-page: 417
  issue: 5
  year: 2002
  ident: ref25
  article-title: Polymorphism in codons 10 and 25 of the transforming growth factor-beta 1 (TGF-beta1) gene in patients with invasive squamous cell carcinoma of the uterine cervix
  publication-title: Eur J Immunogenet
  doi: 10.1046/j.1365-2370.2002.00347.x
  contributor:
    fullname: Stanczuk GA
– volume: 348
  start-page: 518
  issue: 6
  year: 2003
  ident: ref20
  article-title: Epidemiologic classification of human papillomavirus types associated with cervical cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa021641
  contributor:
    fullname: Muñoz N
– volume: 91
  start-page: 3602
  issue: 9
  year: 1994
  ident: ref30
  article-title: p53 and E2F-1 cooperate to mediate apoptosis
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.91.9.3602
  contributor:
    fullname: Wu X
– volume: 94
  start-page: 3052
  issue: 7
  year: 1997
  ident: ref17
  article-title: Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.7.3052
  contributor:
    fullname: Knall C
– volume: 85
  start-page: 2526
  issue: 12
  year: 1999
  ident: ref16
  article-title: Serum IL-6 level reflects the tumor proliferative activity in patients with colorectal cancer
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19990615)85:12<2526::AID-CNCR6>3.0.CO;2-3
  contributor:
    fullname: Kinoshita T
– volume: 8
  start-page: 713
  issue: 6
  year: 2012
  ident: ref22
  article-title: Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment
  publication-title: Future Oncol
  doi: 10.2217/fon.12.59
  contributor:
    fullname: Palena C
– volume: 10
  start-page: 600
  issue: 2
  year: 2015
  ident: ref24
  article-title: Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer
  publication-title: Oncol Lett
  doi: 10.3892/ol.2015.3295
  contributor:
    fullname: Song D
– volume: 102
  start-page: 1369
  issue: 7
  year: 1998
  ident: ref11
  article-title: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
  publication-title: J Clin Invest
  doi: 10.1172/JCI2629
  contributor:
    fullname: Fishman D
– volume: 37
  start-page: 363
  issue: 5
  year: 2004
  ident: ref15
  article-title: Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
  publication-title: Clin Biochem
  doi: 10.1016/j.clinbiochem.2004.01.014
  contributor:
    fullname: Kassim SK
– volume: 23
  start-page: 2078
  issue: 9
  year: 2005
  ident: ref9
  article-title: Role of transforming growth factor β in human cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2005.02.047
  contributor:
    fullname: Elliott RL
– volume: 13
  start-page: 1547
  issue: 9
  year: 2004
  ident: ref23
  article-title: Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.1547.13.9
  contributor:
    fullname: Savage SA
– volume: 140
  start-page: 241
  issue: 2
  year: 2008
  ident: ref10
  article-title: A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions
  publication-title: Eur J Obstet Gynecol Reprod Biol
  doi: 10.1016/j.ejogrb.2008.04.007
  contributor:
    fullname: Fernandes APM
– volume: 14
  start-page: 2457
  issue: 10
  year: 2005
  ident: ref5
  article-title: Lack of association between -251T>A polymorphism of IL8 and lung cancer risk
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-05-0446
  contributor:
    fullname: Campa D
– volume: 6
  start-page: 2702
  issue: 7
  year: 2000
  ident: ref21
  article-title: Serum interleukin 6 as a prognostic factor in patients with prostate cancer
  publication-title: Clin Cancer Res
  contributor:
    fullname: Nakashima J
– volume: 59
  start-page: 145
  issue: 1
  year: 2012
  ident: ref29
  article-title: Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2012.04.013
  contributor:
    fullname: Wang Y
– year: 2013
  ident: ref18
  article-title: The association of the immune response genes to human papillomavirus-related cervical disease in a Brazilian population
  publication-title: BioMed Res Int
  doi: 10.1155/2013/146079
  contributor:
    fullname: Marangon AV
– year: 2002
  ident: ref1
– volume: 127
  start-page: 701
  issue: 3
  year: 2011
  ident: ref2
  article-title: Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2010.11.050
  contributor:
    fullname: Akdis M
– volume: 53
  start-page: 282
  issue: 3
  year: 2011
  ident: ref3
  article-title: Increased plasma levels of adipokines and inflammatory markers in older women with persistent HPV infection
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2010.11.014
  contributor:
    fullname: Baker R
– volume: 7
  start-page: 122
  issue: 2
  year: 2005
  ident: ref4
  article-title: The role of Interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
  publication-title: Neuro-oncol
  doi: 10.1215/S1152851704001061
  contributor:
    fullname: Brat DJ
– volume: 31
  start-page: 35
  year: 2003
  ident: ref28
  article-title: Chapter 5: viral and host factors in human papillomavirus persistence and progression
  publication-title: J Natl Cancer Inst Monogr
  doi: 10.1093/oxfordjournals.jncimonographs.a003480
  contributor:
    fullname: Wang SS
– volume: 69
  start-page: 413
  issue: 2
  year: 2001
  ident: ref12
  article-title: Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus
  publication-title: Am J Hum Genet
  doi: 10.1086/321291
  contributor:
    fullname: Hull J
– year: 2012
  ident: ref13
– volume: 2
  start-page: 342
  issue: 5
  year: 2002
  ident: ref31
  article-title: Papillomaviruses and cancer: from basic studies to clinical application
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc798
  contributor:
    fullname: zur Hausen H
– volume: 15
  start-page: 209
  issue: 2
  year: 2014
  ident: ref26
  article-title: Pharmacogenomic implications of population admixture: Brazil as a model case
  publication-title: Pharmacogenomics
  doi: 10.2217/pgs.13.238
  contributor:
    fullname: Suárez-Kurtz G
– volume: 91
  start-page: 3602
  issue: 9
  year: 1994
  end-page: 3606
  article-title: p53 and E2F-1 cooperate to mediate apoptosis
  publication-title: Proc Natl Acad Sci USA
– volume: 59
  start-page: 145
  issue: 1
  year: 2012
  end-page: 155
  article-title: Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion
  publication-title: Cytokine
– volume: 14
  start-page: 2457
  issue: 10
  year: 2005
  end-page: 2458
  article-title: Lack of association between -251T>A polymorphism of IL8 and lung cancer risk
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 37
  start-page: 363
  issue: 5
  year: 2004
  end-page: 369
  article-title: Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
  publication-title: Clin Biochem
– year: 2012
  publication-title: GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012
– volume: 63
  start-page: 2610
  issue: 10
  year: 2003
  end-page: 2615
  article-title: A transforming growth factor β1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer
  publication-title: Cancer Res
– volume: 140
  start-page: 241
  issue: 2
  year: 2008
  end-page: 244
  article-title: A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions
  publication-title: Eur J Obstet Gynecol Reprod Biol
– volume: 94
  start-page: 3052
  issue: 7
  year: 1997
  end-page: 3057
  article-title: Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases
  publication-title: Proc Natl Acad Sci USA
– volume: 8
  start-page: 713
  issue: 6
  year: 2012
  end-page: 722
  article-title: Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment
  publication-title: Future Oncol
– volume: 53
  start-page: 282
  issue: 3
  year: 2011
  end-page: 285
  article-title: Increased plasma levels of adipokines and inflammatory markers in older women with persistent HPV infection
  publication-title: Cytokine
– volume: 14
  start-page: 2876
  issue: 1
  year: 2015
  end-page: 2884
  article-title: A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil
  publication-title: Genet Mol Res
– year: 2002
  publication-title: Nomenclatura para laudos Colposcópico 2002
– volume: 348
  start-page: 518
  issue: 6
  year: 2003
  end-page: 527
  article-title: Epidemiologic classification of human papillomavirus types associated with cervical cancer
  publication-title: N Engl J Med
– volume: 2
  start-page: 342
  issue: 5
  year: 2002
  end-page: 350
  article-title: Papillomaviruses and cancer: from basic studies to clinical application
  publication-title: Nat Rev Cancer
– volume: 21
  start-page: 45
  issue: 1
  year: 2001
  end-page: 52
  article-title: Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicator
  publication-title: J Interferon Cytokine Res
– volume: 69
  start-page: 413
  issue: 2
  year: 2001
  end-page: 419
  article-title: Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus
  publication-title: Am J Hum Genet
– volume: 6
  start-page: 2702
  issue: 7
  year: 2000
  end-page: 2706
  article-title: Serum interleukin 6 as a prognostic factor in patients with prostate cancer
  publication-title: Clin Cancer Res
– year: 2016
  publication-title: Estimativa de Câncer no Brasil 2016/2017
– volume: 85
  start-page: 2526
  issue: 12
  year: 1999
  end-page: 2531
  article-title: Serum IL-6 level reflects the tumor proliferative activity in patients with colorectal cancer
  publication-title: Cancer
– volume: 65
  start-page: 131
  issue: 1
  year: 2001
  end-page: 150
  article-title: Molecular pathways in virus induced cytokine production
  publication-title: Microbiol Mol Biol Rev
– year: 2013
  article-title: The association of the immune response genes to human papillomavirus-related cervical disease in a Brazilian population
  publication-title: BioMed Res Int
– volume: 23
  start-page: 2078
  issue: 9
  year: 2005
  end-page: 2093
  article-title: Role of transforming growth factor β in human cancer
  publication-title: J Clin Oncol
– volume: 31
  start-page: 35
  year: 2003
  end-page: 40
  article-title: Chapter 5: viral and host factors in human papillomavirus persistence and progression
  publication-title: J Natl Cancer Inst Monogr
– volume: 10
  start-page: 600
  issue: 2
  year: 2015
  end-page: 606
  article-title: Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer
  publication-title: Oncol Lett
– volume: 15
  start-page: 209
  issue: 2
  year: 2014
  end-page: 219
  article-title: Pharmacogenomic implications of population admixture: Brazil as a model case
  publication-title: Pharmacogenomics
– volume: 29
  start-page: 417
  issue: 5
  year: 2002
  end-page: 421
  article-title: Polymorphism in codons 10 and 25 of the transforming growth factor-beta 1 (TGF-beta1) gene in patients with invasive squamous cell carcinoma of the uterine cervix
  publication-title: Eur J Immunogenet
– volume: 127
  start-page: 701
  issue: 3
  year: 2011
  end-page: 721
  article-title: Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
  publication-title: J Allergy Clin Immunol
– volume: 13
  start-page: 1547
  issue: 9
  year: 2004
  end-page: 1549
  article-title: Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 158
  start-page: 330
  issue: 2
  year: 2011
  end-page: 333
  article-title: Association between cytokine gene polymorphisms and cervical cancer in a Chinese population
  publication-title: Eur J Obstet Gynecol Reprod Biol
– volume: 7
  start-page: 122
  issue: 2
  year: 2005
  end-page: 133
  article-title: The role of Interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
  publication-title: Neuro-oncol
– volume: 102
  start-page: 1369
  issue: 7
  year: 1998
  end-page: 1376
  article-title: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
  publication-title: J Clin Invest
SSID ssj0027364
Score 2.267559
Snippet Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer....
Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer....
SourceID doaj
scielo
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 663
SubjectTerms Adolescent
Adult
Aged
Alleles
Base Sequence
Brazil
Cervical Intraepithelial Neoplasia - genetics
Cervical Intraepithelial Neoplasia - virology
Cross-Sectional Studies
cytokine
DNA, Viral - analysis
Female
Gene Frequency
Genetic Predisposition to Disease
host genome
HPV
Humans
Interleukin-6 - genetics
Interleukin-8 - genetics
Middle Aged
Papillomavirus Infections - genetics
Papillomavirus Infections - virology
PARASITOLOGY
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
polymorphisms
Transforming Growth Factor beta1 - genetics
TROPICAL MEDICINE
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - virology
Young Adult
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3ditQwFA6yiHgj_ltXJYIgwpRNJk2aXrriuCuuCO7C3oUkTbHQSYfpjhf7AD6QD-IzeU5_hhkUvPGmhf4mOSfnfCcn-ULIK8mdLhgOVNkCApQAfa5gXqc-6Ezo0odM4wLns8_q5CL7eCkvd7b6wjlhAz3w0HBHOs8d-OxgrS8yGZjDM7cOzKoWqhqYQFkxBVNTqCV64igOphhssGJjglIW7AidJmYukYcEVXLPIfW8_X8Dm3_OmbyJLqrZ9UaLu-TOCCPp26H498iNEO-TW2djovwB-XE6bT5C24qefkrVDI96Rm0s6fmHRfrrJ6egPIGu2gbif2juult2tI0UICHFGef4Zr-FH13ZVd007dJ-r9ebLp0mcEVaR9pTOFBcpUK_4Nji0m18O6PHa3tdNw_JxeL9-buTdNxyIfUY6aRqbjEXAzBRywDePdfcO5ULKZyoimCltVZIVvEgteMVlzb4wlunwBlCqKjEI3IQ2xieECqZlRzAI7dVyKCxQYqai6z0mWZBlWVC3kztblYDs4bBiARkZFBGZkdGCTlGwWyfQ07s_gJoihk1xfxLUxLychKrgT6EiREbQ7vpDJg1qQBacZaQx4OYt7-a5znE8DxPSL6nAHtl2b8T6289TzdgKckyePP1oCpmNA-d-bqt4LyvIfL2AfR7-j-qeUhu40eH9ZLPyMHVehOeA3C6ci_6PvIb1y8Pmw
  priority: 102
  providerName: Directory of Open Access Journals
Title Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil
URI https://www.ncbi.nlm.nih.gov/pubmed/27783717
https://search.proquest.com/docview/1835674110
https://pubmed.ncbi.nlm.nih.gov/PMC5125047
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016001100663&lng=en&tlng=en
https://doaj.org/article/877b644eaac945e0bac941ab284836f4
Volume 111
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtQwELXaCiFeEHfCpTISEkLadOPGTpxHWrFtEYsq0Ur7Ftlep0TKTZsuEnwAH8SH8E3MOPHSFTzx4ihXx55jz4w9PibktWBaZhEOVKkMHBQLbS6LjAyNlTyWS2O5xAXO80_J6SX_sBCLHSL8WhgXtG90edBU9UFTfnGxlV1tpj5ObHo-PwYlJSKeTnfJLgDUu-jey4oHzigMNIQzPzcpMnD__TWkVQM0IhNwmoKL5rYr-6OWHHv_v0zOvyMnb6Giqm7qpNk9cnc0Jum74afvkx3bPCC35-N0-UPy48xvQULbgp59DJMJpnJCVbOkFyez8NdPRgFClnZt9a1uodLLvu5p21AwDCnGneObbiM_2qmurKq2Vl_L1boPfRhXQ8uGOiIHimtV6DmOMNZ6bdoJPVqp72X1iFzO3l8cn4bjxguhQX8nTA4VzsiAsSiFBR2fSmZ0ksYi1nGRWSWUUrGICmaF1KxgQlmTGaUTUIngMCbxY7LXtI19SqiIlGBgQjJVWA71rhMuWcyXhsvIJstlQN76es-7gV8jR78ExJWjuPIb4grIEQpm8xwyY7sL7eoqH_GRyzSFPLhVymRc2EjjkSkNaljGScED8sqLNYeWhNMjqrHtus-hcxMJGFgsCsiTQcybrDxMApJuAWDrX7bvAHgdW_cI1oC8GaCSj51En3_eFPDQlRDZ-8AAfPbfeTwnd_BLw1LJF2TverW2L8Fmutb7bqwB0pMF23ft5Tc2HRHA
link.rule.ids 230,315,730,783,787,867,888,2109,27936,27937,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bjtMwELWWBQEviDvhaiQkhNRs442dOI_sitJCu1qJrrRvlu04ECk3tVsk-AA-iA_hm5jJpWwFT7wkinOx45nxzNjjM4S8EszIJMCJKp2Ag-JA5pLASt86yUOZWsclbnBenETTM_7hXJzvETHshWmD9q3JD6qiPKjyL21sZVPa8RAnNj5dHIOSEgGPx1fIVZDXgA9O-uBnhR1qFIYawtWwOimSYLwtQ2A14EfEAo5jcNLahGV_FFOL3_8vo_Pv2MlrqKqKy1ppcpvc6s1J-rZr9h2y56q75PqiXzC_R37MhiQktM7obO5HIzzKEdVVSpfvJ_6vn4wCEzna1MW3soZuz9flmtYVBdOQYuQ5vtmm8qONbvKiqEv9NV9t1v4QyFXRvKItlAPF3Sr0FOcYS7Ox9YgerfT3vLhPzibvlsdTv0-94Fv0ePzoUOOaDJiLUjjQ8rFk1kRxKEITZonTQmsdiiBjTkjDMia0s4nVJgKlCC5jFD4g-1VduUeEikALBkYk05nj0O8m4pKFPLVcBi5KU4-8GfpdNR3ChkLPBMilkFzqErk8coSE2T6H2NhtQb36rHoOUTKOoQ7utLYJFy4weGbagCKWYZRxj7wcyKpAlnCBRFeu3qwVDG8iAhOLBR552JF5W9XAJh6Jdxhgpy27d4B9W7zunl098rpjFdUPE2v1afuDh-0fIn4fmICP_7uOF-TGdLmYq_ns5OMTchO_2m2cfEr2L1Yb9wwsqAvzvJWX3-ZXEzA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtQwELWgoKoviDspNyMhIaRNEze24zzSwtKFbrUSrdQ3y3YciJSbNl0k-AA-iA_hmxjnsuwKnnhJFOdixzP2zHjGZxB6yYgWSegWqlQCBoqFMZeERvjGChqJ1Fgq3Abn-Rk_uaAfLtnlRqqvLmjf6PygKsqDKv_SxVY2pQnGOLFgMT8GIcVCGgdNmgXX0Q0YsyEfDfXR1op65CgXbghXo4eSJWGwLnPgasCTDg84jsFQ65KW_RFOHYb_vxTPv-MnbzpxVWxKpultdGtQKfGbvul30DVb3UW788Fpfg_9mI2JSHCd4dmpzyfuKCZYVSk-fz_1f_0kGBjJ4qYuvpU1dH3eli2uKwzqIXbR5-7NLp0fblSTF0Vdqq_5ctX6YzBXhfMKd3AO2O1YwQu3zljqlakn-GipvufFfXQxfXd-fOIP6Rd846wenx8q55cBlVEwC5I-FsRoHkcs0lGWWMWUUhELM2KZ0CQjTFmTGKU5CEYwG3n0AO1UdWUfIcxCxQgokkRllkK_a04FiWhqqAgtT1MPvR77XTY9yoZ01gmQSzpyyQ1yeejIEWb9nMPH7grq5Wc5cIkUcQx1UKuUSSizoXZnojQIYxHxjHroxUhWCePJOUlUZetVK2GKYxzULBJ66GFP5nVVI5t4KN5igK22bN8BFu4wuweW9dCrnlXkMFW08tP6Bw-7P3QYfqAG7v93Hc_R7uLtVJ7Ozj4-Rnvuo_3eySdo52q5sk9BibrSz7rh8hvwbhRD
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+IL-6%2C+IL-8%2C+and+TGF-%CE%B21+gene+polymorphisms+on+the+risk+of+human+papillomavirus-infection+in+women+from+Pernambuco%2C+Brazil&rft.jtitle=Mem%C3%B3rias+do+Instituto+Oswaldo+Cruz&rft.au=Lima+J%C3%BAnior%2C+S%C3%A9rgio+Ferreira+de&rft.au=Tavares%2C+Mayara+Mansur+Fernandes&rft.au=Macedo%2C+Jamilly+Lopes+de&rft.au=Oliveira%2C+Renata+Santos+de&rft.date=2016-11-01&rft.issn=0074-0276&rft.eissn=1678-8060&rft.volume=111&rft.issue=11&rft.spage=663&rft.epage=669&rft_id=info:doi/10.1590%2F0074-02760160051&rft.externalDBID=n%2Fa&rft.externalDocID=10_1590_0074_02760160051
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0074-0276&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0074-0276&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0074-0276&client=summon