Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review

• Published in: Case reports in obstetrics and gynecology Vol. 2017; no. 2017; pp. 1 - 4
• Main Authors: Imran, N., Alsamsam, Adham, Patwardhan, Manasi, Awadalla, Michael
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Blood pressure; Care and treatment; Case Report; Case studies; Genetic disorders; Health aspects; Health risk assessment; Kidney diseases; Mutation; Pregnancy, Complications of; Rodents; Sodium; Sodium channels; Detroit Michigan

Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension....