Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review

Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension....

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Published inCase reports in obstetrics and gynecology Vol. 2017; no. 2017; pp. 1 - 4
Main Authors Imran, N., Alsamsam, Adham, Patwardhan, Manasi, Awadalla, Michael
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Blood pressure
Care and treatment
Case Report
Case studies
Genetic disorders
Health aspects
Health risk assessment
Kidney diseases
Mutation
Pregnancy, Complications of
Rodents
Sodium
Sodium channels
Detroit Michigan
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Summary:Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27-year-old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day.
Bibliography:Academic Editor: Michael Geary
ISSN:2090-6684
2090-6692
DOI:10.1155/2017/6279460