New Drugs and Promising Drug Combinations in the Treatment of Chagas Disease in Brazil: A Systematic Review and Meta-Analysis

• Published in: Archives of medical research Vol. 56; no. 1; p. 103084
• Main Authors: Freire, Elainne Silva, da Silva, Letícia Pinto, Silva, Aline do Carmo, Vaz de Castro, Pedro Alves Soares, de Araújo, Giovanna Rotondo, Otta, Dayane Andriotti, Braz, Danilo Cavalcante, Bezerra, Juliana Maria Trindade
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025
• Subjects: Brazil; Brazil - epidemiology; Chagas disease; Chagas Disease - drug therapy; Chagas Disease - epidemiology; Chagas Disease - parasitology; Drug Combinations; Drug Therapy, Combination; Humans; Nitroimidazoles - therapeutic use; Therapies under study; Trypanocidal Agents - therapeutic use; Trypanosoma cruzi; Trypanosoma cruzi - drug effects; Trypanosoma cruzi - pathogenicity; Brazil; Chagas disease; Brazil; Therapies under study; Trypanosoma cruzi
• ISSN: 0188-4409; 1873-5487; 1873-5487
• DOI: 10.1016/j.arcmed.2024.103084

Chagas disease (CD) is a parasitic infection caused by the protozoan Trypanosoma cruzi (Kinetoplastida, Trypanosomatidae). Benznidazole (Bz) has a limited ability to interfere with the pathogenicity of the parasite, which manages to overcome host defenses. This study aimed to conduct a systematic literature review and meta-analysis to understand and describe the drugs and their combinations, as well as new promising compounds used in the treatment of CD in Brazil. This study was registered in the Open Science Framework (OSF) and the International Prospective Register of Systematic Reviews, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were performed in the electronic scientific databases PubMed, LILACS, SciELO, and BVS. Searches were conducted using descriptors cataloged in the Health Sciences Descriptors (DeCS) and Medical Subject Headings (MeSH), in Portuguese, English, and Spanish. Of the 26 articles included in this systematic review and meta-analysis, 16 were related to drug combinations, and nine described new inhibitors of parasitic molecules. Despite high heterogeneity (I2 = 92%), studies that evaluated the combination of Bz with other treatments for CD had an overall grouped cure rate of 74% (95% CI 54–94%). Only one study presented drug repositioning by monotherapy. Thus, drug combinations offer quick and accessible solutions for CD treatment, acting against resistant strains of T. cruzi. Certainly, the introduction of these promising compounds into the pharmaceutical market is distant, and the adoption of prophylactic measures is recommended as a barrier to the increasing number of CD cases.