Early detection of breast and ovarian cancer in families with BRCA mutations

Women at risk of breast and ovarian cancer due to a genetic predisposition may opt for preventive surgery or surveillance. The aim of this study was to determine the effectiveness of surveillance in families with a BRCA mutation. Sixty-eight BRCA-families underwent surveillance using annual mammogra...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of cancer (1990) Vol. 41; no. 4; pp. 549 - 554
Main Authors Vasen, H.F.A., Tesfay, E., Boonstra, H., Mourits, M.J.E., Rutgers, E., Verheyen, R., Oosterwijk, J., Beex, L.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2005
Elsevier
Subjects
Adult
Aged
Biological and medical sciences
BRCA
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Breast Neoplasms - surgery
CA-125 Antigen - blood
Cohort Studies
Early Diagnosis
Female
Genes, BRCA1
Genes, BRCA2
Humans
Medical sciences
Middle Aged
Mutation - genetics
Ovarian cancer
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - genetics
Ovarian Neoplasms - surgery
Pedigree
Pharmacology. Drug treatments
Prospective Studies
Risk Factors
Surveillance
Tumors
BRCA
Breast cancer
Surveillance
Ovarian cancer
Ovary cancer
Pharmacology
Malignant tumor
Female genital diseases
Ovarian diseases
Mammary gland diseases
Cancerology
Genetics
Diagnosis
Mutation
Online AccessGet full text

Cover

More Information
Summary:Women at risk of breast and ovarian cancer due to a genetic predisposition may opt for preventive surgery or surveillance. The aim of this study was to determine the effectiveness of surveillance in families with a BRCA mutation. Sixty-eight BRCA-families underwent surveillance using annual mammography, transvaginal ultrasound, and estimation of CA125. Two hundred and two women had at least one breast examination, and 138 at least one examination of the ovaries. After a mean follow-up of 33 months, breast cancer was detected in 21 women, four with lymph node metastases. After a mean follow-up of 37 months, six advanced ovarian cancers were detected. The percentage of metastatic breast cancers in the current study appeared to be acceptable. However, because these women have a high-risk of developing breast cancer, they still have a substantial risk of developing metastatic disease under surveillance. Surveillance for ovarian cancer was not effective.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2004.10.029