Macrophage physiology in the eye

The eye is a complex sensory organ composed of a range of tissue types including epithelia, connective tissue, smooth muscle, vascular and neural tissue. While some components of the eye require a high level of transparency to allow light to pass through unobstructed, other tissues are characterized...

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Bibliographic Details
Published inPflügers Archiv Vol. 469; no. 3-4; pp. 501 - 515
Main Authors Chinnery, Holly R, McMenamin, Paul G, Dando, Samantha J
Format Journal Article Book Review
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2017
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Eye - physiopathology
Human Physiology
Humans
Invited Review
Macrophages - physiology
Molecular Medicine
Neurosciences
Receptors
Eye
Retina
Cornea
Uvea
Macrophage
Microglia
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Summary:The eye is a complex sensory organ composed of a range of tissue types including epithelia, connective tissue, smooth muscle, vascular and neural tissue. While some components of the eye require a high level of transparency to allow light to pass through unobstructed, other tissues are characterized by their dense pigmentation, which functions to absorb light and thus control its passage through the ocular structures. Macrophages are present in all ocular tissues, from the cornea at the anterior surface through to the choroid/sclera at the posterior pole. This review will describe the current understanding of the distribution, phenotype, and physiological role of ocular macrophages, and provide a summary of evidence pertaining to their proposed role during pathological conditions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-017-1947-5