Packed-bed bioreactor synthesis of feruloylated monoacyl- and diacylglycerols: clean production of a green sunscreen

A biocatalytic process for covalent incorporation of ferulic acid onto the glycerol backbone of vegetable oil proceeds efficiently, although rather slowly, with Candida antarctica lipase B in a packed-bed reactor. The bioreactor shows considerable long-term stability. Product yield is influenced by...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 5; no. 4; pp. 382 - 386
Main Authors Laszlo, Joseph A, Compton, David L, Eller, Fred J, Taylor, Scott L, Isbell, Terry A
Format Journal Article
LanguageEnglish
Published 01.01.2003
Subjects
Adsorption
Bioreactors
biotechnology
Candida antarctica
Diacylglycerol
diacylglycerols
Enzymes
equipment design
Ferulic acid
Glycerol
green development
immobilized enzymes
Oil
personal care products
Sunscreens
Triacylglycerol lipase
ultraviolet radiation
vegetable oil
Vegetables
Water content
yields
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Summary:A biocatalytic process for covalent incorporation of ferulic acid onto the glycerol backbone of vegetable oil proceeds efficiently, although rather slowly, with Candida antarctica lipase B in a packed-bed reactor. The bioreactor shows considerable long-term stability. Product yield is influenced by the water content of the fluid phase and enzyme support. The enzyme support modulates substrate concentrations through adsorption and subsequent release of reactants over the course of the reaction. The resulting product has excellent UVA/UVB absorbing properties, making it a potential substitute for conventional petroleum-based sunscreen active agents.
Bibliography:http://hdl.handle.net/10113/20183
http://dx.doi.org/10.1039/b302384b
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ISSN:1463-9262
1463-9270
DOI:10.1039/b302384b