A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro

A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprote...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 10; no. 8; pp. 835 - 838
Main Authors LARGET, R, LOCKHART, B, RENARD, P, LARGERON, M
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 17.04.2000
Subjects
Biological and medical sciences
Chemical Sciences
Flavonoids - chemical synthesis
Flavonoids - chemistry
Flavonoids - pharmacology
In Vitro Techniques
Life Sciences
Medical sciences
Medicinal Chemistry
Neurons and Cognition
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - chemical synthesis
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Organic chemistry
Pharmacology. Drug treatments
Structure-Activity Relationship
Chemical rearrangement
Neuroprotective agent
Oxygen heterocycle
Flavonoid
In vitro
Aminophenols
Polyphenol
Structure activity relation
Animal
Bicyclic compound
Phenols
Aromatic compound
Chemical synthesis
Antioxidants
Substituent effects
Radical scavengers
Neuroprotective agents
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Summary:A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprotective agents in vitro.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00110-4