Maternal serum alpha-fetoprotein and fetal autosomal trisomies

Maternal serum alpha-fetoprotein values in 61 patients with fetal autosomal trisomies diagnosed at 6581 genetic amniocenteses were significantly lower than those in an equal number of matched control subjects. The genetic risk of fetal autosomal trisomies for women less than age 35 offered amniocent...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 154; no. 2; p. 277
Main Authors Doran, T A, Cadesky, K, Wong, P Y, Mastrogiacomo, C, Capello, T
Format Journal Article
LanguageEnglish
Published United States 01.02.1986
Subjects
Adult
alpha-Fetoproteins - analysis
Amniocentesis
Chromosome Aberrations - diagnosis
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosomes, Human, 13-15
Chromosomes, Human, 16-18
Down Syndrome - diagnosis
Down Syndrome - genetics
Female
Fetal Diseases - diagnosis
Fetal Diseases - genetics
Genetic Testing
Humans
Maternal Age
Pregnancy
Pregnancy, High-Risk
Prenatal Diagnosis
Risk
Trisomy
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Summary:Maternal serum alpha-fetoprotein values in 61 patients with fetal autosomal trisomies diagnosed at 6581 genetic amniocenteses were significantly lower than those in an equal number of matched control subjects. The genetic risk of fetal autosomal trisomies for women less than age 35 offered amniocentesis with maternal serum alpha-fetoprotein values less than 0.5 multiples of the median is in the same range as that currently accepted for advanced maternal age. Maternal serum alpha-fetoprotein screening for autosomal trisomies (mainly Down syndrome) is feasible.
ISSN:0002-9378
DOI:10.1016/0002-9378(86)90655-1