Large deviations estimates for the multiscale analysis of heart rate variability

• Published in: Physica A Vol. 391; no. 22; pp. 5658 - 5671
• Main Authors: Loiseau, Patrick, Médigue, Claire, Gonçalves, Paulo, Attia, Najmeddine, Seuret, Stéphane, Cottin, François, Chemla, Denis, Sorine, Michel, Barral, Julien
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.11.2012; Elsevier
• Subjects: Blinds; Cardiology and cardiovascular system; Computer Science; Deviation; Engineering Sciences; Estimators; Heart rate; Heart rate variability; Human; Human health and pathology; Large deviations; Life Sciences; Multifractal analysis; Multiscale analysis; Signal and Image processing; Singularities; Time series; Large deviations; Heart rate variability; Multifractal analysis; Multiscale analysis
• ISSN: 0378-4371; 1873-2119; 0378-4371
• DOI: 10.1016/j.physa.2012.05.069

In the realm of multiscale signal analysis, multifractal analysis provides a natural and rich framework to measure the roughness of a time series. As such, it has drawn special attention of both mathematicians and practitioners, and led them to characterize relevant physiological factors impacting the heart rate variability. Notwithstanding these considerable progresses, multifractal analysis almost exclusively developed around the concept of Legendre singularity spectrum, for which efficient and elaborate estimators exist, but which are structurally blind to subtle features like non-concavity or, to a certain extent, non scaling of the distributions. Large deviations theory allows bypassing these limitations but it is only very recently that performing estimators were proposed to reliably compute the corresponding large deviations singularity spectrum. In this article, we illustrate the relevance of this approach, on both theoretical objects and on human heart rate signals from the Physionet public database. As conjectured, we verify that large deviations principles reveal significant information that otherwise remains hidden with classical approaches, and which can be reminiscent of some physiological characteristics. In particular we quantify the presence/absence of scale invariance of RR signals. ► We estimate large-deviations spectra of heart-rate signals. ► RR signals spectra have non-concavity linked to extrasystoles. ► RR signals do not have uniform scale invariance. ► We propose a measure of non-scaling. ► Our measure of non-scaling classifies subjects according to their pathology.