Identification of compounds with antipyretic effects and anti-endotoxin activity in different species of Lonicera japonica using spectrum-effect correlation

Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum-effect correlation method was...

Full description

Saved in:
Bibliographic Details
Published inExperimental and therapeutic medicine Vol. 22; no. 1; p. 665
Main Authors Ding, Jing-Xin, Liu, Chang, Liu, Xiong-Wei, Yan, Wei-Na, Li, Wen-Pei, Shi, Hui, Li, Jia-Xin, Tang, Cheng-Lin, Zhou, Ying
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.07.2021
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Acids
Antipyretics
Body temperature
Chinese medicine
Cytokines
Drug dosages
Health aspects
Heat
Honeysuckle
Hypothalamus
Oral administration
Pharmaceuticals
Pharmacodynamics
Plant products
Quality control
Quality standards
Testing
China
antipyretic effect
spectrum-effect correlation
anti-endotoxin activity
key substances
Lonicera japonica
Online AccessGet full text

Cover

More Information
Summary:Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum-effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti-endotoxin activity of . The common chemical constituents of were analyzed using LC, and the antipyretic effects and anti-endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti-endotoxin activity. The present study lays a foundation for the future clinical use of .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Abbreviations: TCM, Traditional Chinese Medicine; HPLC, high-performance liquid chromatography; LJT, Lonicera japonica Thunb.; LFH, Lonicera fulvotomentosa Hsu et S. C. Cheng; LMH, Lonicera macranthoides Hand.-Mazz.; NCA, neochlorogenic acid; CA, chlorogenic acid; CCA, cryptochlorogenic acid; SLA, secologanic acid; SL, secoxyloganin; ICAB, isochlorogenic acid B; ICAA, isochlorogenic acid A; ICAC, isochlorogenic acid C; LPS, lipopolysaccharide; AVP, arginine vasopressin; ET, endotoxin; BA, bivariate analysis; PCA, principal component analysis
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10097