Lack of association between interferon‐gamma receptor‐1 polymorphism and pulmonary TB in Iranian population sample

• Published in: The Journal of infection Vol. 52; no. 5; pp. 374 - 377
• Main Authors: Mirsaeidi, S.M., Houshmand, M., Tabarsi, P., Banoei, M.M., Zargari, L., Amiri, M., Mansouri, S.D., Sanati, M.H., Masjedi, M.R.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.05.2006; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Female; General aspects; Genetic Predisposition to Disease - genetics; Genetical susceptibility; Humans; IFN-γR1; Interferon gamma Receptor; Iran - epidemiology; Male; Medical sciences; Middle Aged; Mutation; Mycobacterium; Polymorphism, Genetic; Receptors, Interferon - genetics; Risk Factors; Tuberculosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - genetics; Iran; IFN-γR1; Tuberculosis; Genetical susceptibility; Infection; Lung; Gamma interferon; Polymorphism
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1016/j.jinf.2005.08.009

Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-γR1. Determination of susceptibility to tuberculosis with polymorphism of IFN-γR1 gene. Study was prospective case–control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-γR1 gene was detected with Newport method. Data were analysed with SPSS version 11. Mean age of patients and control were 55±20 and 53±13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-γR1 gene. In control group there were no mutations. Genetically susceptibility to TB is not in 395 colon of IFN-γR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population.