New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

• Published in: Acta cirurgica brasileira Vol. 34; no. 12; p. e201901201
• Main Authors: Macêdo, Clóvis Ney Pinheiro, Braga, Francisco Evanilso Silva, Campelo, Ana Paula Bomfim Soares, Diniz, Gabriel Maia, Lopes, Luiz Gonzaga de França, Kubrusly, Marcos, Campelo, Marcio Wilker Soares
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.01.2019
• Subjects: 2,2'-Dipyridyl - analogs & derivatives; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Fractals; Kidney; Kidney Diseases - chemically induced; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Male; Meloxicam - adverse effects; Nitric Oxide Donors - pharmacology; Organometallic Compounds - pharmacology; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Ruthenium; Ruthenium - pharmacology
• ISSN: 0102-8650; 1678-2674
• DOI: 10.1590/s0102-865020190120000001

To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Rut-bpy may prevent renal histological changes in rats caused by meloxicam.