A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions

A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show artiproliferative activities similar to discodermolide. A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifica...

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Published inBioorganic & medicinal chemistry letters Vol. 16; no. 7; pp. 1961 - 1964
Main Authors Shaw, Simon J., Sundermann, Kurt F., Burlingame, Mark A., Zhang, Dan, Petryka, Joseph, Myles, David C.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.2006
Elsevier
Subjects
Analogues
Antineoplastic agents
Antitumor
Biological and medical sciences
Cell Line, Tumor
Discodermolide
General aspects
Humans
Lactones - chemistry
Medical sciences
Pharmacology. Drug treatments
Triterpenes - chemistry
Analogues
Discodermolide
Antitumor
Antineoplastic agent
Human
Lung
Furan derivatives
Lactone
Organic carbamate
In vitro
Biological activity
Polyketide
Cell line
Polyenic compound
Mammary gland
Chemical synthesis
Tumor cell
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Summary:A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show artiproliferative activities similar to discodermolide. A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show antiproliferative activities similar to discodermolide.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.12.066