Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach to enhance the delivery of such dru...

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Bibliographic Details
Published inFrontiers in Drug Delivery Vol. 3
Main Authors Mohite, Popat, Singh, Sudarshan, Pawar, Anil, Sangale, Adinath, Prajapati, Bhupendra G.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 24.08.2023
Subjects
BCS-II
bioavailability
Drug Delivery
improved solubility
lipids
oral drug delivery
stability
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Summary:Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach to enhance the delivery of such drugs. Moreover, encapsulation within capsules to provide a convenient dosage form for oral administration. The encapsulation techniques are optimized to ensure uniform drug content and efficient encapsulation efficiency. Several investigations demonstrated that the lipid-based formulations in capsules significantly improved the solubility and dissolution rate of poorly water-soluble drugs compared to non-lipid formulations. Additionally, the encapsulation of lipid-based formulations protected the drug against degradation and improved its stability. Overall, incorporating lipid-based formulations in capsules represents a promising strategy for enhancing the delivery of poorly water-soluble drugs with improvement in solubility, dissolution, stability, and bioavailability, overcoming the challenges associated with these challenging drug molecules. The review focussed a brief on utilization of lipids in capsule form to improve therapeutic efficacy of poorly soluble, dissolution and bioavailability of drugs.
Bibliography:Supandeep Singh Hallan, Riga Stradiņš University, Latvia
Edited by: Sajeesh Thampi, Lehigh University, United States
Reviewed by: Salome Amarachi Chime, University of Nigeria, Nsukka, Nigeria
Nadeem Irfan Bukhari, University of the Punjab, Pakistan
Present address: Sudarshan Singh, Office of Research Administration, Chiang Mai University, Chiang Mai, Thailand
ISSN:2674-0850
2674-0850
DOI:10.3389/fddev.2023.1232012