Serum Lipocalin 2 (Neutrophil Gelatinase-Associated Lipocalin) in Relation to Biomarkers of Inflammation and Cardiac Stretch During Activation of the Renin-Angiotensin-Aldosterone System in Human Immunodeficiency Virus

• Published in: The Journal of infectious diseases Vol. 220; no. 9; pp. 1420 - 1424
• Main Authors: Bogorodskaya, Milana, Fitch, Kathleen V, Burdo, Tricia H, Maehler, Patrick, Easly, Rebecca M, Murray, Gillian R, Feldpausch, Meghan, Adler, Gail K, Grinspoon, Steven K, Srinivasa, Suman
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2019
• Subjects: Adolescent; Adult; Aged; Aldosterone; Angiotensin; Biomarkers; Biomarkers - blood; Brain natriuretic peptide; Cardiovascular Diseases - pathology; CD163 antigen; Cell activation; Chemokines; Female; Gelatinase; Heart; HIV; HIV Infections - complications; Human immunodeficiency virus; Humans; Inflammation; Inflammation - complications; Lipocalin; Lipocalin-2 - blood; Macrophages; Major and Brief Reports; Male; Middle Aged; Monocytes; Nutrient deficiency; Peptides; Prospective Studies; Renin; Renin-Angiotensin System; Serum - chemistry; Tumor necrosis factor-α; Young Adult; renin-angiotensin-aldosterone system; lipocalin 2; HIV; BNP; inflammation
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jiz346

To evaluate the relationship of lipocalin 2 to inflammation and cardiac injury with increased aldosterone in human immunodeficiency virus (HIV). A standardized 6-day low-sodium diet was used to stimulate renin-angiotensin-aldosterone system (RAAS) activation, and serum lipocalin 2 and biomarkers of inflammation and cardiac stretch were assessed among persons with or without HIV. Lipocalin 2 levels increased with RAAS activation compared with suppression in the HIV group (median level [interquartile range], 71.3 [59.2-99.7] vs 67.0 [51.8-86.3] ng/mL; P = .01). During RAAS activation, lipocalin 2 was related to biomarkers of inflammation (tumor necrosis factor α [P = .007]), monocyte/macrophage activation (soluble CD163 [P = .005] and chemokine [C-C motif] ligand 2 [P = .03]), and markers of cardiac stretch (brain natriuretic peptide [P < .001] and N-terminal fragment of the prohormone brain natriuretic peptide [P = .001]) in HIV. Lipocalin 2 may be important in modulating aldosterone-induced inflammation, monocyte activation, and cardiac stretch during RAAS activation in HIV. NCT01407237.