Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice
Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, f...
Saved in:
| Published in | Neural regeneration research Vol. 7; no. 33; pp. 2565 - 2575 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications & Media Pvt. Ltd
25.11.2012
College of Pharmacy,Hebei North University,Zhangjiakou 075000,Hebei Province,China Medknow Publications & Media Pvt Ltd |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, followed by treatment with 40, 20, or 10 mg/kg orientin, vitexin, or a positive control （vitamin E） via intragastric administration for an additional 8 weeks. Orientin, vitexin, and vitamin E improved the general medical status of the aging mice and significantly increased their brain weights. They also produced an obvious rise in total antioxidant capacity, superoxide dismutase, catalase, and glutathione peroxidase levels in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na＋-K＋-ATP enzyme, and Ca2＋-Mg2＋-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced malondialdehyde levels in the liver, brain and kidney and lipofuscin levels in the brain. They also significantly improved the neuronal ultrastructure. The 40 mg/kg dose of orientin and vitexin had the same antioxidant capacity as vitamin E. These experimental findings indicate that orientin and vitexin engender anti-aging effects through their antioxidant capacities. |
|---|---|
| Bibliography: | Trollius chinesis Bunge orientin vitexin total flavonoids in Trollius Total flavonoids are the main pharmaceutical components of Trollius chinensis Bunge, and orientin and vitexin are the monomer components of total flavonoids in Trollius chinensis Bunge. In this study, an aged mouse model was established through intraperitoneal injection of D-galactose for 8 weeks, followed by treatment with 40, 20, or 10 mg/kg orientin, vitexin, or a positive control （vitamin E） via intragastric administration for an additional 8 weeks. Orientin, vitexin, and vitamin E improved the general medical status of the aging mice and significantly increased their brain weights. They also produced an obvious rise in total antioxidant capacity, superoxide dismutase, catalase, and glutathione peroxidase levels in the serum, and the levels of superoxide dismutase, catalase and glutathione peroxidase, Na＋-K＋-ATP enzyme, and Ca2＋-Mg2＋-ATP enzyme in the liver, brain and kidneys. In addition, they significantly reduced malondialdehyde levels in the liver, brain and kidney and lipofuscin levels in the brain. They also significantly improved the neuronal ultrastructure. The 40 mg/kg dose of orientin and vitexin had the same antioxidant capacity as vitamin E. These experimental findings indicate that orientin and vitexin engender anti-aging effects through their antioxidant capacities. Fang An, Guodong Yang, Jiaming Tian, Shuhua Wang （College of Pharmacy, Hebei North University, Zhangjiakou 075000, Hebei Province, China） 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author statements: The manuscript is original, has not been submitted to or is not under consideration by another publication, has not been previously published in any language or any form, including electronic, and contains no disclosure of confidential information or authorship/patent application disputations. Fang An, Master, Professor, College of Pharmacy, Hebei North University, Zhangjiakou 075000, Hebei Province, China Author contributions: Fang An and Guodong Yang conceived and designed the study, conducted the majority of the experiments, and wrote the manuscript. Jiaming Tian contributed to data collection and completed the statistical analyses. Shuhua Wang revised the manuscript, approved the final version to be published, and was responsible for funding. |
| ISSN: | 1673-5374 1876-7958 |
| DOI: | 10.3969/j.issn.1673-5374.2012.33.001 |