Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model

Background/Aim: In the present study, we evaluated the efficacy of adjuvant administration of oral recombinant methioninase (o-rMETase) against recurrence and metastasis in a 4T1 murine breast-cancer syngeneic model. Materials and Methods: 4T1 cells were orthotopically implanted into the 2nd mammary...

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Published inAnticancer research Vol. 40; no. 9; pp. 4869 - 4874
Main Authors SUGISAWA, NORIHIKO, HAMADA, KAZUYUKI, HAN, QINGHONG, YAMAMOTO, JUN, SUN, YU, NISHINO, HIROTO, KAWAGUCHI, KEI, BOUVET, MICHAEL, UNNO, MICHIAKI, HOFFMAN, ROBERT M.
Format Journal Article
LanguageEnglish
Published Athens International Institute of Anticancer Research 01.09.2020
Subjects
Breast cancer
Cancer
Lung cancer
Lung nodules
Lungs
Metastases
Metastasis
Nodules
Tumors
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Summary:Background/Aim: In the present study, we evaluated the efficacy of adjuvant administration of oral recombinant methioninase (o-rMETase) against recurrence and metastasis in a 4T1 murine breast-cancer syngeneic model. Materials and Methods: 4T1 cells were orthotopically implanted into the 2nd mammary fat pad of BALB/c mice. The 4T1 orthotopic syngeneic models were randomized into 2 groups after primary tumor resection: untreated control and o-rMETase (100 units, oral, daily, 2 weeks). Results: The frequency and extent of local recurrence were reduced by o-rMETase. The number of individual cancer cells and metastatic nodules on the lung surface was significantly lower in the o-rMETase-treated mice than the untreated control mice. Conclusion: Adjuvant o-rMETase inhibited local recurrence and lung metastasis after primary tumor resection.
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ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14489