MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and...

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Bibliographic Details
Published inJournal of clinical medicine Vol. 4; no. 9; pp. 1688 - 1712
Main Authors Pisarello, Maria Jose Lorenzo, Loarca, Lorena, Ivanics, Tommy, Morton, Leslie, LaRusso, Nicholas
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 26.08.2015
Subjects
General Medicine
Review
cholangiopathies
microRNA
cholangiocarcinoma
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Summary:The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm4091688