Bufadienolides and polyhydroxycholestane derivatives from Bufo bufo gargarizans

A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7- oxo -5β - cholestane 26- O -sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analysis. A comparison of steroi...

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Published inJournal of asian natural products research Vol. 17; no. 4; pp. 364 - 376
Main Authors Wang, Yan-Min, Li, Zong-Yun, Wang, Jing-Jing, Wu, Xi-Yan, Gao, Hui-Min, Wang, Zhi-Min
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 03.04.2015
Taylor & Francis Ltd
Subjects
Animals
bufadienolide
bufadienolides
Bufanolides - chemistry
Bufanolides - isolation & purification
Bufo bufo
Bufo bufo gargarizans
Chemistry
Chemistry, Applied
Chemistry, Medicinal
China
Cholestanols - chemistry
Cholestanols - isolation & purification
Chromatography, High Pressure Liquid
high performance liquid chromatography
Life Sciences & Biomedicine
metabolites
Molecular Structure
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
polyhydroxycholestane sulfate
Science & Technology
Skin
Skin - chemistry
sulfates
toad skin
toad venom
toads
Venoms
China
toad skin
Bufo bufo gargarizans
STEROIDS
polyhydroxycholestane sulfate
toad venom
IDENTIFICATION
bufadienolide
CANCER
MASS-SPECTROMETRY
CYTOTOXIC BUFADIENOLIDES
TOAD
SKIN
CONSTITUENTS
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Abstract A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7- oxo -5β - cholestane 26- O -sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analysis. A comparison of steroidal metabolite profiles, based on HPLC and LC–MS analyses, indicates that the chemical compositions of the various parts of toads, such as venom, skin and stratum corneum, are significantly different.
AbstractList A new polyhydroxycholestane sulfate ester, 3 alpha,12 beta,25,26-tetrahydroxy-7-oxo-5 beta-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analysis. A comparison of steroidal metabolite profiles, based on HPLC and LC-MS analyses, indicates that the chemical compositions of the various parts of toads, such as venom, skin and stratum corneum, are significantly different.
A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7-oxo-5β-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analysis. A comparison of steroidal metabolite profiles, based on HPLC and LC-MS analyses, indicates that the chemical compositions of the various parts of toads, such as venom, skin and stratum corneum, are significantly different.
A new polyhydroxycholestane sulfate ester, 3α,12[beta],25,26-tetrahydroxy-7-oxo-5[beta]-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo gargarizans Cantor and its structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analysis. A comparison of steroidal metabolite profiles, based on HPLC and LC-MS analyses, indicates that the chemical compositions of the various parts of toads, such as venom, skin and stratum corneum, are significantly different.
Author Wang, Yan-Min
Wang, Jing-Jing
Gao, Hui-Min
Wu, Xi-Yan
Li, Zong-Yun
Wang, Zhi-Min
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Keywords toad skin
Bufo bufo gargarizans
STEROIDS
polyhydroxycholestane sulfate
toad venom
IDENTIFICATION
bufadienolide
CANCER
MASS-SPECTROMETRY
CYTOTOXIC BUFADIENOLIDES
TOAD
SKIN
CONSTITUENTS
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Snippet A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7- oxo -5β - cholestane 26- O -sulfate (1), was isolated from dried skin of Bufo bufo...
A new polyhydroxycholestane sulfate ester, 3α,12β,25,26-tetrahydroxy-7-oxo-5β-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo...
A new polyhydroxycholestane sulfate ester, 3 alpha,12 beta,25,26-tetrahydroxy-7-oxo-5 beta-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo...
A new polyhydroxycholestane sulfate ester, 3α,12[beta],25,26-tetrahydroxy-7-oxo-5[beta]-cholestane 26-O-sulfate (1), was isolated from dried skin of Bufo bufo...
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SubjectTerms Animals
bufadienolide
bufadienolides
Bufanolides - chemistry
Bufanolides - isolation & purification
Bufo bufo
Bufo bufo gargarizans
Chemistry
Chemistry, Applied
Chemistry, Medicinal
China
Cholestanols - chemistry
Cholestanols - isolation & purification
Chromatography, High Pressure Liquid
high performance liquid chromatography
Life Sciences & Biomedicine
metabolites
Molecular Structure
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
polyhydroxycholestane sulfate
Science & Technology
Skin
Skin - chemistry
sulfates
toad skin
toad venom
toads
Venoms
Title Bufadienolides and polyhydroxycholestane derivatives from Bufo bufo gargarizans
URI https://www.tandfonline.com/doi/abs/10.1080/10286020.2014.995174
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https://www.ncbi.nlm.nih.gov/pubmed/25819343
https://www.proquest.com/docview/1668322076
https://search.proquest.com/docview/1669840978
Volume 17
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